Monoamines and their metabolites in cerebrospinal fluid and temporal cortex of epileptic patients

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dc.contributor.authorNaffahMazzacoratti, M. G.
dc.contributor.authorAmado, D.
dc.contributor.authorCukiert, A.
dc.contributor.authorGronich, G.
dc.contributor.authorMarino, R.
dc.contributor.authorCalderazzo, L.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:34Z
dc.date.available2016-01-24T11:40:34Z
dc.date.issued1996-10-01
dc.description.abstractThe involvement of monoamines in the initiation or maintenance of epileptic phenomena has been extensively studied in cerebral tissues and in cerebrospinal fluid. the present work was undertaken to study monoamines and their metabolites in human spiking and non-spiking temporal cortex excised from patients with complex partial seizures unresponsive to available anticonvulsants. the same substances were also analyzed by HPLC-ED in cerebrospinal fluid obtained 24 h before the surgical procedure and compared with those from patients with chronic headache and normal neurological evaluation. the results show increased 5-HT, 5-HIAA and HVA levels in spiking compared with non-spiking cortex. Cerebrospinal fluid levels of 5-HIAA and HVA are concomitantly increased in epileptic compared with headache patients.en
dc.description.affiliationUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,LAB NEUROCIENCIA,RUA BOTUCATU,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,LAB NEUROCIENCIA,RUA BOTUCATU,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent133-137
dc.identifierhttp://dx.doi.org/10.1016/0920-1211(96)00030-7
dc.identifier.citationEpilepsy Research. Amsterdam: Elsevier B.V., v. 25, n. 2, p. 133-137, 1996.
dc.identifier.doi10.1016/0920-1211(96)00030-7
dc.identifier.issn0920-1211
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25629
dc.identifier.wosWOS:A1996VH59600007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmonoamineen
dc.subjectepilepsyen
dc.subjectcortexen
dc.subjectcerebrospinal fluiden
dc.titleMonoamines and their metabolites in cerebrospinal fluid and temporal cortex of epileptic patientsen
dc.typeinfo:eu-repo/semantics/article
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