Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze

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dc.contributor.authorNascimento, Juliana Olivetti Guzman [UNIFESP]
dc.contributor.authorKikuchi, Leticia Sumiko [UNIFESP]
dc.contributor.authorBortoli, Valquiria Camin de
dc.contributor.authorZangrossi, Helio
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Espirito Santo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:37:56Z
dc.date.available2016-01-24T14:37:56Z
dc.date.issued2014-10-01
dc.description.abstractThe dorsomedial hypothalamus (DMH) has long been associated with the regulation of escape, a panicrelated defensive response. Previous evidence has shown that the activation of serotonin (5-HT) 1A and 2A receptors impairs escape behavior induced by the electrical stimulation of the same region. in this study we further explore the relationship of the DMH with defense by investigating the effects of 5-HT1A activation on escape behavior generated in male Wistar rats by an ethologically based aversive stimuli, exposure to one of the open arms of the elevated T-maze (ETM). Aside from escape, the ETM also allows the measurement of inhibitory avoidance, a defensive response associated with generalized anxiety disorder. To evaluate locomotor activity, after ETM measurements animals were submitted to an open field. Results showed that intra-DMH administration of the 5-HT1A receptor agonist 8-OH-DPAT inhibited escape expression. Local administration of the 5-HT1A antagonist WAY-100635 by its own was ineffective, but blocked the panicolytic-like effect of 8-OH-DPAT. Chronic (21 days) systemic treatment with imipramine potentiated the anti-escape effect of 8-OH-DPAT. No significant effects of treatment with 8-OH-DPAT or imipramine on avoidance latencies or the number of lines crossed in the open field were found: These results indicate that 5-HT1A receptors within the DMH may play a phasic inhibitory role on ETM escape expression. As previously proposed, facilitation of 5-HT1A-mediated neurotransmission in the DMH may be involved in the mechanism of action of anti-panic compounds. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria & Psicol Med, BR-04038020 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, Brazil
dc.description.affiliationUniv Fed Espirito Santo, Dept Ciancias Saude, BR-29932540 Sao Mateus, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Farmacol, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria & Psicol Med, BR-04038020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, Brazil
dc.description.sourceWeb of Science
dc.format.extent39-45
dc.identifierhttps://dx.doi.org/10.1016/j.brainresbull.2014.09.011
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 109, p. 39-45, 2014.
dc.identifier.doi10.1016/j.brainresbull.2014.09.011
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38282
dc.identifier.wosWOS:000347596800005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPanicen
dc.subjectEscapeen
dc.subjectSerotonin 1A receptorsen
dc.subjectDorsomedial hypothalamusen
dc.subjectElevated T-mazeen
dc.titleDorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-mazeen
dc.typeinfo:eu-repo/semantics/article
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