Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

Página do item simplificado
dc.contributor.authorPompeia, Sabine [UNIFESP]
dc.contributor.authorGrego, Bruno H. C. [UNIFESP]
dc.contributor.authorPradella-Hallinan, Marcia [UNIFESP]
dc.contributor.authorHachul, Helena [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorD'Almeida, Vania [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:38Z
dc.date.available2016-01-24T13:58:38Z
dc.date.issued2009-08-31
dc.description.abstractPurpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, could decrease homocysteine, and if changes were similar in both genders.Methods: This was a double-blind, cross-over design study of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n = 21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of flunitrazepam was reached). Various biochemical parameters were analysed, such as plasma homocysteine, cysteine, folate, vitamins B6, B12, and sexual hormones.Results: Flunitrazepam reduced cortisol (p = 0.0011), cysteine (p = 0.014) and homocysteine (p = 0.028) concentrations, irrespective of gender. No correlations were found between cortisol and other biochemical markers (all r's<0.03). Concentration of cysteine and homocysteine were negatively correlated with plasma flunitrazepam concentration, suggesting that changes in these amino acids might be related to the metabolism of this benzodiazepine.Conclusion: Acute administration of flunitrazepam decreases plasma homocysteine and cysteine by mechanisms that seem unrelated to changes in cortisol. Given the importance of homocysteine as a market of life-threatening disorders, the mechanisms involved in the decrease of these amino acids are potential targets for clinical application. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipAFIP
dc.description.sponsorshipIDFAPESP: 2005/03552-8
dc.description.sponsorshipIDFAPESP: 2003/00046-9
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent933-938
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2009.04.017
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 33, n. 6, p. 933-938, 2009.
dc.identifier.doi10.1016/j.pnpbp.2009.04.017
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31750
dc.identifier.wosWOS:000269300600003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBenzodiazepineen
dc.subjectCortisolen
dc.subjectCysteineen
dc.subjectGenderen
dc.subjectHomocysteineen
dc.titleAcute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteersen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Outras produções