Effects of lorazepam on visual perceptual abilities

Página do item simplificado
dc.contributor.authorPompeia, S. [UNIFESP]
dc.contributor.authorPradella-Hallinan, M. [UNIFESP]
dc.contributor.authorManzano, G. M. [UNIFESP]
dc.contributor.authorBueno, O. F. A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:42Z
dc.date.available2016-01-24T13:49:42Z
dc.date.issued2008-04-01
dc.description.abstractObjective To evaluate the effects of an acute dose of the benzodiazepine (BZ) lorazepam in young healthy volunteers on five distinguishable visual perception abilities determined by previous factor-analytic studies.Methods This was a double-blind, cross-over design study of acute oral doses of lorazepam (2 mg) and placebo in young healthy volunteers. We focused on a set of paper-and-pencil tests of visual perceptual abilities that load on five correlated but distinguishable factors (Spatial Visualization, Spatial Relations, Perceptual Speed, Closure Speed, and Closure Flexibility). Some other tests (DSST, immediate and delayed recall of prose; measures of subjective mood alterations) were used to control for the classic BZ-induced effects.Results Lorazepam impaired performance in the DSST and delayed recall of prose, increased subjective sedation and impaired tasks of all abilities except Spatial Visualization and Closure Speed. Only impairment in Perceptual Speed (Identical Pictures task) and delayed recall of prose were not explained by sedation.Conclusion Acute administration of lorazepam, in a dose that impaired episodic memory, selectively affected different visual perceptual abilities before and after controlling for sedation. Central executive demands and sedation did not account for results, so impairment in the Identical Pictures task may be attributed to lorazeparn's visual processing alterations. Copyright (c) 2008 John Wiley & Sons, Ltd.en
dc.description.affiliationUniversidade Federal de São Paulo, Dep Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dep Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent183-192
dc.identifierhttp://dx.doi.org/10.1002/hup.927
dc.identifier.citationHuman Psychopharmacology-clinical and Experimental. Chichester: John Wiley & Sons Ltd, v. 23, n. 3, p. 183-192, 2008.
dc.identifier.doi10.1002/hup.927
dc.identifier.issn0885-6222
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30546
dc.identifier.wosWOS:000255116100002
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHuman Psychopharmacology-clinical and Experimental
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectlorazepamen
dc.subjectbenzodiazepinesen
dc.subjectvisual abilitiesen
dc.subjectcentral executiveen
dc.subjectworking memoryen
dc.subjectperformanceen
dc.titleEffects of lorazepam on visual perceptual abilitiesen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral