The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy

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dc.contributor.authorMatos, Gabriela
dc.contributor.authorTsai, Rodrigo
dc.contributor.authorBaldo, Marcus Vinicius
dc.contributor.authorCastro, Isac de [UNIFESP]
dc.contributor.authorSameshima, Koichi
dc.contributor.authorValle, Angela Cristina
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:26Z
dc.date.available2016-01-24T13:59:26Z
dc.date.issued2010-03-01
dc.description.abstractThe relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. the pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. the aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. the architecture of the sleep-wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Pathol, Sch Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Stat, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Neurol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Radiol, Sch Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent324-331
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2009.11.015
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 17, n. 3, p. 324-331, 2010.
dc.identifier.doi10.1016/j.yebeh.2009.11.015
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32359
dc.identifier.wosWOS:000276029900004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep-wake cycleen
dc.subjectEpilepsyen
dc.subjectPilocarpineen
dc.subjectStatus epilepticusen
dc.subjectSeizuresen
dc.titleThe sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsyen
dc.typeinfo:eu-repo/semantics/article
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