Distinct effects of paradoxical sleep deprivation and cocaine administration on sexual behavior in male rats

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:21Z
dc.date.available2016-01-24T12:33:21Z
dc.date.issued2002-04-01
dc.description.abstractAs there are data showing enhanced sexual activity in paradoxical sleep deprived (PSD) rats, and cocaine (COC) is a drug of abuse known to also increase the sexual drive, the present study aimed to assess sexual behavior in animals submitted to PSD and/or COC administration. the data revealed that PSD followed by COC administration produced the largest percentage of animals having erection and ejaculation (100% and 60%) and differ statistically from the control groups. the PSD group that received saline produced 50% erections and 20% ejaculations whereas COC administration induced 10% erections and 10% ejaculations. Sexual activity was absent in control animals (saline injection). These findings are due probably to PSD causing supersensitivity of dopamine (DA) receptors exacerbating the cocaine actions on dopaminergic pathways inducing penile erection and ejaculation.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent251-253
dc.identifierhttps://dx.doi.org/10.1080/135562102200120497
dc.identifier.citationAddiction Biology. Basingstoke: Carfax Publishing, v. 7, n. 2, p. 251-253, 2002.
dc.identifier.doi10.1080/135562102200120497
dc.identifier.issn1355-6215
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/26829
dc.identifier.wosWOS:000175201800008
dc.language.isoeng
dc.publisherCarfax Publishing
dc.relation.ispartofAddiction Biology
dc.rightsAcesso restrito
dc.titleDistinct effects of paradoxical sleep deprivation and cocaine administration on sexual behavior in male ratsen
dc.typeArtigo
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