Chlorella vulgaris treatment ameliorates the suppressive effects of single and repeated stressors on hematopoiesis

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dc.contributor.authorQueiroz, Julia de Souza
dc.contributor.authorBarbosa, Christiano Marcello Vaz [UNIFESP]
dc.contributor.authorRocha, Michelle C. da
dc.contributor.authorBincoletto, Claudia [UNIFESP]
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.contributor.authorSouza Queiroz, Mary Luci de Souza
dc.contributor.authorPalermo Neto, João
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:31:17Z
dc.date.available2016-01-24T14:31:17Z
dc.date.issued2013-03-01
dc.description.abstractThe reports regarding the mutual influence between the central nervous system and the immune system constitute a vast and somewhat controversial body of literature. Stress is known to disturb homeostasis, impairing immunological functions. in this study, we investigated the hematopoietic response of Chlorella vulgaris (CV)-treated mice exposed to single (SST) and repeated stress (RST). We observed a reduction in the numbers of hematopoietic progenitors (HP) in the bone marrow and long-term bone marrow cultures (LTBMC) using flow cytometry and a coinciding decrease in the number of granulocyte-macrophage colonies (CFU-GM) after treatment with both stressors, but SST caused a more profound suppression. We observed a proportional increase in the colony-stimulating activity (CSA) of the serum of animals subjected to SST or RST. in the bone marrow, SST and RST induced a decrease in both mature myeloid and lymphoid populations but did not affect pluripotent hematopoietic progenitors (Lin(-)Sca-1(+)c-kit(+), LSK), and again, a more profound suppression was observed after SST. We further quantified the levels of interleukin-1 alpha (IL-1 alpha) and interleukin-6 (IL-6) and the number of myeloid cells in LTBMC. Both SST and RST reduced the levels of these cytokines to similar degrees. the myeloid population was also reduced in LTBMC, and SST induced a more intense suppression. Importantly, CV treatment prevented the changes produced by SST and RST in all of the parameters evaluated. Together, our results suggest that CV treatment is an effective tool for the prophylaxis of myelosuppression caused by single or repeated stressors. (c) 2012 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas UNICAMP, Fac Ciencias Med, Dept Farmacol, Campinas, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biofis, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet, Grp Pesquisa Neuroimunomodulacao, BR-05508000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biofis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 09/51886-3
dc.description.sponsorshipIDCNPq: 300764/2010-3
dc.format.extent39-50
dc.identifierhttp://dx.doi.org/10.1016/j.bbi.2012.12.001
dc.identifier.citationBrain Behavior and Immunity. San Diego: Academic Press Inc Elsevier Science, v. 29, p. 39-50, 2013.
dc.identifier.doi10.1016/j.bbi.2012.12.001
dc.identifier.fileWOS000315365400005.pdf
dc.identifier.issn0889-1591
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35990
dc.identifier.wosWOS:000315365400005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Behavior and Immunity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChlorella vulgarisen
dc.subjectSingle stressoren
dc.subjectRepeated stressoren
dc.subjectHematopoiesisen
dc.subjectFlow cytometryen
dc.subjectLong-term bone marrow cultureen
dc.subjectCFU-GMen
dc.subjectCytokinesen
dc.titleChlorella vulgaris treatment ameliorates the suppressive effects of single and repeated stressors on hematopoiesisen
dc.typeinfo:eu-repo/semantics/article
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