Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis

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dc.citation.volume7
dc.contributor.authorMelo, Brunno Lemes de [UNIFESP]
dc.contributor.authorVieira, Stella de Souza [UNIFESP]
dc.contributor.authorAntonio, Ednei Luiz [UNIFESP]
dc.contributor.authorSantos, Luis Felipe Neves dos [UNIFESP]
dc.contributor.authorPortes, Leslie Andrews [UNIFESP]
dc.contributor.authorFeliciano, Regiane S.
dc.contributor.authorde Oliveira, Helenita A.
dc.contributor.authorSilva, Jose A., Jr.
dc.contributor.authorde Carvalho, Paulo de Tarso C.
dc.contributor.authorTucci, Paulo José Ferreira [UNIFESP]
dc.contributor.authorSerra, Andrey Jorge [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-31T12:47:04Z
dc.date.available2020-07-31T12:47:04Z
dc.date.issued2016
dc.description.abstractIntroduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV. Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeriesen
dc.description.abstractthere is often the need for another surgery during passage to adulthooden
dc.description.abstractpatients with mild stenosis may have later cardiac adverse repercussions. Thus, the search for approaches to counteract the long-term PAS effects showed to be a current target. At the study herein, we evaluated the cardioprotective role of exercise training in rats submitted to PAS for 9 weeks. Methods and Results: Exercise resulted in improved physical fitness and systolic RV function. Exercise also blunted concentric cavity changes, diastolic dysfunction, and fibrosis induced by PAS. Exercise additional benefits were also reported in a pro-survival signal, in which there were increased Akt(1) activity and normalized myocardial apoptosis. These findings were accompanied by microRNA-1 downregulation and microRNA-21 upregulation. Moreover, exercise was associated with a higher myocardial abundance of the sarcomeric protein alpha-MHC and proteins that modulate calcium handling ryanodine receptor and Serca 2, supporting the potential role of exercise in improving myocardial performance. Conclusion: Our results represent the first demonstration that exercise can attenuate the RV remodeling in an experimental PAS. The cardioprotective effects were associated with positive modulation of RV function, survival signaling pathway, apoptosis, and proteins involved in the regulation of myocardial contractility.en
dc.description.affiliationUniv Fed Sao Paulo, Cardiac Physiol Lab, Sao Paulo, Brazil
dc.description.affiliationNove de Julho Univ, Biophoton Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespCardiac Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 09-54225/8
dc.description.sponsorshipIDFAPESP: 2015/11028-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fphys.2016.00541
dc.identifier.citationFrontiers In Physiology. Lausanne, v. 7, p. -, 2016.
dc.identifier.doi10.3389/fphys.2016.00541
dc.identifier.fileWOS000389156800001.pdf
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56559
dc.identifier.wosWOS:000389156800001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectartery pulmonary stenosisen
dc.subjectcardiac hypertrophyen
dc.subjectcardiac remodelingen
dc.subjectexercise trainingen
dc.subjectright ventricular hypertrophyen
dc.titleExercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosisen
dc.typeinfo:eu-repo/semantics/article
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