Brain SPECT imaging in Sydenham's chorea

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dc.contributor.authorBarsottini, Orlando Graziani Povoas [UNIFESP]
dc.contributor.authorFerraz, H.b. [UNIFESP]
dc.contributor.authorSevillano, Marta Maite [UNIFESP]
dc.contributor.authorBarbieri, A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:29:39Z
dc.date.available2015-06-14T13:29:39Z
dc.date.issued2002-04-01
dc.description.abstractThe objective of the present study was to determine whether brain single-photon emission computed tomography (SPECT) imaging is capable of detecting perfusional abnormalities. Ten Sydenham's chorea (SC) patients, eight females and two males, 8 to 25 years of age (mean 13.4), with a clinical diagnosis of SC were submitted to brain SPECT imaging. We used HMPAO labeled with technetium-99m at a dose of 740 MBq. Six examinations revealed hyperperfusion of the basal ganglia, while the remaining four were normal. The six patients with abnormal results were females and their data were not correlated with severity of symptoms. Patients with abnormal brain SPECT had a more recent onset of symptoms (mean of 49 days) compared to those with normal SPECT (mean of 85 days) but this difference did not reach statistical significance. Brain SPECT can be a helpful method to determine abnormalities of the basal ganglia in SC patients but further studies on a larger number of patients are needed in order to detect the phase of the disease during which the examination is more sensitive.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Neurologia Setor de Distúrbios do Movimento
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Diagnóstico por Imagem Setor de Medicina Nuclear
dc.description.affiliationUnifespUNIFESP, Depto. de Neurologia Setor de Distúrbios do Movimento
dc.description.affiliationUnifespUNIFESP, Depto. de Diagnóstico por Imagem Setor de Medicina Nuclear
dc.description.sourceSciELO
dc.format.extent431-436
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000400004
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 4, p. 431-436, 2002.
dc.identifier.doi10.1590/S0100-879X2002000400004
dc.identifier.fileS0100-879X2002000400004.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2002000400004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1397
dc.identifier.wosWOS:000175259700004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSydenham's choreaen
dc.subjectSingle-photon emission computed tomographyen
dc.subjectSPECT imagingen
dc.subjectRheumatic feveren
dc.subjectBrain perfusionen
dc.titleBrain SPECT imaging in Sydenham's choreaen
dc.typeinfo:eu-repo/semantics/article
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