Analysis of ICAM-1 and HLA-DR expression on renal allograft aspirates

Página do item simplificado
dc.contributor.authorManfro, Roberto Ceratti [UNIFESP]
dc.contributor.authorGoncalves, LFS
dc.contributor.authorRauber, M.
dc.contributor.authorMoura, Luiz Antonio Ribeiro de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:05:06Z
dc.date.available2018-06-15T17:05:06Z
dc.date.issued1996-08-01
dc.description.abstractICAM-1 and HLA-DR expressions were studied on parenchymal cells obtained by aspirative biopsies of renal allografts. Patients were evaluated during 3 months after transplantation. Conventional cytology and immunoperoxidase stainings using anti-ICAM-1 and anti-HLA-DR antibodies were employed. The value of the total corrected increment was significantly higher (p<0.05) during acute rejection episodes than during acute tubular necrosis or stable renal function, The percentage of HLA-DR positive cells were higher in rejection than in stable function periods (p<0.05). The percentage of ICAM-1 positive cells was higher in rejection than in acute tubular necrosis periods (p<0.05). The sensitivities to the diagnosis of rejection were 71.8% (TCI) 68.4% (ICAM-1) and 55.0% (HLA-DR). The specificities were 87.3%, 81.3% and 68.4% respectively. Combinations of the tests resulted in increased sensitivity. We concluded that the use of these monoclonal antibodies improves the sensitivity of conventional aspiration cytology to the diagnosis of acute renal rejection.en
dc.description.affiliationESCOLA PAULISTA MED,POST GRAD NEPHROL COURSE,SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,POST GRAD NEPHROL COURSE,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent379-383
dc.identifier.citationClinical Transplantation. Copenhagen: Munksgaard Int Publ Ltd, v. 10, n. 4, p. 379-383, 1996.
dc.identifier.issn0902-0063
dc.identifier.urihttp://repositorio.unifesp.br/11600/43390
dc.identifier.wosWOS:A1996VH54900010
dc.language.isoeng
dc.publisherMunksgaard Int Publ Ltd
dc.relation.ispartofClinical Transplantation
dc.rightsAcesso restrito
dc.subjectacute rejectionen
dc.subjectfine needle aspiration biopsyen
dc.subjectHLA-DRen
dc.subjectICAM-1en
dc.subjectkidney transplantationen
dc.titleAnalysis of ICAM-1 and HLA-DR expression on renal allograft aspiratesen
dc.typeArtigo
Arquivos
Coleções
EPM - Artigos