Supplementation with Selenium Can Influence Nausea, Fatigue, Physical, Renal, and Liver Function of Children and Adolescents with Cancer

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dc.contributor.authorSantos Vieira, Maria Luiza dos
dc.contributor.authorAffonso Fonseca, Fernando Luiz [UNIFESP]
dc.contributor.authorCosta, Larissa Grossi
dc.contributor.authorBeltrame, Registila Libania
dc.contributor.authorSousa Chaves, Carolina Machado de
dc.contributor.authorCartum, Jairo
dc.contributor.authorAlves, Sarah Isabel P. M. do N. [UNIFESP]
dc.contributor.authorAzzalis, Ligia Ajaime [UNIFESP]
dc.contributor.authorCampos Junqueira, Virginia Berlanga [UNIFESP]
dc.contributor.authorPereira, Edimar Cristiano [UNIFESP]
dc.contributor.authorRocha, Katya Cristina
dc.contributor.institutionFac Med ABC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:39:51Z
dc.date.available2016-01-24T14:39:51Z
dc.date.issued2015-01-01
dc.description.abstractThe drugs used in chemotherapy treatments have little specificity, attack tumor cells, and also injure proliferative tissues. Knowledge of the functions of micronutrients has greatly increased, especially of Selenium (Se) that presents immunomodulatory and antitumor functions. the present study evaluated the health-related quality of life of patients undergoing chemotherapy for the treatment of leukemias and lymphomas (LL) and solid tumors (ST) while receiving Selenium (Se) supplementation. This is a randomized, double-blind, crossover study that evaluated the quality of life (EORTC-QLQ-C30 questionnaire), renal and liver functions of patients supplemented with Se. There was no statistically significant alteration in LL patients. However, the fatigue and nausea scores after 30 days did decrease in this group as well as in the ST group. After 1 year supplementation with Selenium, a more noticeable decrease in the scores concerning fatigue and nausea could be observed in the ST group, when compared with the beginning of the study. the LL patients also presented a decrease in the fatigue scores and physical functions. the kidney function as well as liver function has improved after Selenium supplementation when compared with the placebo intake in LL and ST patients, more remarkably in the LL group. Supplementation with Selenium promotes the reduction of chemotherapy side effects in cancer patients, especially by improving the conditions of patients with fatigue, nausea, and impaired physical function. Renal and liver functions have also improved.en
dc.description.affiliationFac Med ABC, Dept Patol, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, Brazil
dc.description.sourceWeb of Science
dc.format.extent109-117
dc.identifierhttp://dx.doi.org/10.1089/jmf.2014.0030
dc.identifier.citationJournal of Medicinal Food. New Rochelle: Mary Ann Liebert, Inc, v. 18, n. 1, p. 109-117, 2015.
dc.identifier.doi10.1089/jmf.2014.0030
dc.identifier.issn1096-620X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38605
dc.identifier.wosWOS:000347393400013
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofJournal of Medicinal Food
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectliver functionen
dc.subjectleukemiaen
dc.subjectneoplasiaen
dc.subjectseleniumen
dc.subjectfatigueen
dc.subjectrenal functionen
dc.subjectquality of lifeen
dc.subjectnauseaen
dc.titleSupplementation with Selenium Can Influence Nausea, Fatigue, Physical, Renal, and Liver Function of Children and Adolescents with Canceren
dc.typeinfo:eu-repo/semantics/article
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