Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer

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dc.contributor.authorBadiglian Filho, Levon [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorLima, Flavio de Oliveira [UNIFESP]
dc.contributor.authorCosta, Henrique de Oliveira [UNIFESP]
dc.contributor.authorDamiao, Roberio de Sousa [UNIFESP]
dc.contributor.authorGomes, Thiago Simao [UNIFESP]
dc.contributor.authorGoncalves, Wagner Jose [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:13Z
dc.date.available2016-01-24T13:52:13Z
dc.date.issued2009-02-01
dc.description.abstractThe Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-01424000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 06/51401-1
dc.format.extent313-320
dc.identifierhttp://dx.doi.org/10.3892/or_00000223
dc.identifier.citationOncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.
dc.identifier.doi10.3892/or_00000223
dc.identifier.issn1021-335X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31273
dc.identifier.wosWOS:000262679300006
dc.language.isoeng
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofOncology Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbeta-cateninen
dc.subjectWnt5aen
dc.subjectWnten
dc.subjectFrizzleden
dc.subjectovarian canceren
dc.titleCanonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian canceren
dc.typeinfo:eu-repo/semantics/article
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