Maternally acquired immunity in newborns from women infected by the human immunodeficiency virus

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dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.contributor.authorFarhat, Calil Kairalla [UNIFESP]
dc.contributor.authorCarbonare, Solange B.
dc.contributor.authorCurti, S. P.
dc.contributor.authorOtsubo, MES
dc.contributor.authorLazarotti, D. S.
dc.contributor.authorCampagnoli, R. C.
dc.contributor.authorCarneiro-Sampaio, Magda Maria Sales
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionINST ADOLFO LUTZ REGISTRO
dc.date.accessioned2018-06-15T12:39:56Z
dc.date.available2018-06-15T12:39:56Z
dc.date.issued1993-12-01
dc.description.abstractMaternally acquired immunity was studied in 16 pairs of human immunodeficiency virus (HIV)-seropositive women and their newborns, and was compared to 18 control mother-newborn pairs. The HIV-infected women had higher IgG levels than the control subjects, but no difference was observed between newborn samples, presumably due to the limited placental IgG transfer in the HIV group. A poor type 2 poliovirus antibody transfer was also noted in this group. The population of newborns lacking demonstrable measles antibodies was higher in the HIV group than in the control group, probably because many of the HIV-infected mothers lacked measles antibodies also. These results show that maternally acquired immunity may be affected to newborns from HIV-infected women, either because of low maternal serum antibody levels or deficient transplacental transfer. If so, the measles vaccine schedule should be revised for these children and the same should be done for future passive immunization regarding fetus protection in pregnant HIV-seropositive women.en
dc.description.affiliationUNIV SAO PAULO,DEPT IMMUNOL,BR-05508900 SAO PAULO,SP,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT PEDIAT,SAO PAULO,SP,BRAZIL
dc.description.affiliationINST ADOLFO LUTZ REGISTRO,VIROL SERV,SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PEDIAT,SAO PAULO,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent1034-1038
dc.identifierhttp://dx.doi.org/10.1111/j.1651-2227.1993.tb12805.x
dc.identifier.citationActa Paediatrica. Oslo: Scandinavian University Press, v. 82, n. 12, p. 1034-1038, 1993.
dc.identifier.doi10.1111/j.1651-2227.1993.tb12805.x
dc.identifier.issn0803-5253
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42025
dc.identifier.wosWOS:A1993MT44300008
dc.language.isoeng
dc.publisherScandinavian University Press
dc.relation.ispartofActa Paediatrica
dc.rightsAcesso restrito
dc.subjectACQUIRED IMMUNODEFICIENCY SYNDROMEen
dc.subjectHIVen
dc.subjectIMMUNOGLOBULINSen
dc.subjectMATERNALLY ACQUIRED IMMUNITYen
dc.subjectMEASLESen
dc.subjectPOLIOMYELITISen
dc.titleMaternally acquired immunity in newborns from women infected by the human immunodeficiency virusen
dc.typeArtigo
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