Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

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dc.contributor.authorMoraes, Gabriel da Cunha
dc.contributor.authorVitoretti, Luana Beatriz
dc.contributor.authorBrito, Auriléia Aparecida de
dc.contributor.authorAlves, Cintia Estefano
dc.contributor.authorRigonato-Oliveira, Nicole Cristine
dc.contributor.authorDias, Alana dos Santos
dc.contributor.authorTeles Matos, Yves Silva
dc.contributor.authorOliveira-Junior, Manoel Carneiro
dc.contributor.authorFranco Oliveira, Luis Vicente
dc.contributor.authorPalma, Renata Kelly da
dc.contributor.authorCandeo, Larissa Carbonera
dc.contributor.authorFranco, Adriana Lino dos Santos
dc.contributor.authorHorliana, Anna Carolina Ratto Tempestine
dc.contributor.authorGimenes, Joao Antonio Junior
dc.contributor.authorAimbire, Flavio [UNIFESP]
dc.contributor.authorVieira, Rodolfo de Paula [UNIFESP]
dc.contributor.authorLigeiro-de-Oliveira, Ana Paula
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageLondon
dc.date.accessioned2020-07-02T18:52:00Z
dc.date.available2020-07-02T18:52:00Z
dc.date.issued2018
dc.description.abstractChronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm(2)) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1 beta, IL-6, and TNF-alpha in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.en
dc.description.affiliationUniv Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, SP, Brazil
dc.description.affiliationBrazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Nove Julho UNINOVE, Masters Degree & PhD Program Rehabil Sci, Expt Cardioresp Physiol Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Calif San Diego UCSD Hlth Sci, Div Trauma Surg Crit Care Burns & Acute Care Surg, Dept Surg, San Diego, CA USA
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Brasil, Postgrad Program Bioengn, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 2012/16498-5pt
dc.description.sponsorshipIDFAPESP: 2012/15165-2pt
dc.description.sponsorshipIDFAPESP: 2015/23152-6pt
dc.description.sponsorshipIDFAPESP: 2014/14604-8pt
dc.description.sponsorshipIDFAPESP: 2015/13486-4pt
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1155/2018/6798238
dc.identifier.citationOxidative Medicine And Cellular Longevity. London, v. , p. -, 2018.
dc.identifier.doi10.1155/2018/6798238
dc.identifier.fileWOS000427789900001.pdf
dc.identifier.issn1942-0900
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53817
dc.identifier.wosWOS:000427789900001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofOxidative Medicine And Cellular Longevity
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLow-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptoren
dc.typeinfo:eu-repo/semantics/article
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