Distinct Effects of Intranigral L-DOPA Infusion in the MPTP Rat Model of Parkinson's Disease

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dc.contributor.authorReksidler, Angela B.
dc.contributor.authorLima, Marcelo M. S.
dc.contributor.authorDombrowski, Patricia A.
dc.contributor.authorBarnabe, Gabriela F. [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorVital, Maria A. B. F.
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:02Z
dc.date.available2016-01-24T13:52:02Z
dc.date.issued2009-01-01
dc.description.abstractThe potential neuroprotective or neurotoxic effects of 3,4-dihydroxyphenylalanine (L-DOPA) are yet to be understood. We examined the behavioral, immunohistochemical, tyrosine hydroxylase (TH) expression and neurochemical parameters after an intranigral administration of L-DOPA (10 mu M) in rats.. L-DOPA elicited a 30.5% reduction in dopaminergic neurons, while 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (100 mu g mu L(-1)) produced a 53.6% reduction. A combined infusion of MPTP and L-DOPA generated a 42% reduction of nigral neurons. Motor parameters revealed that both the MPTP and L-DOPA groups presented impairments; however, the concomitant administration evoked a partial restorative effect. in addition, MPTP and L-DOPA separately induced reductions of TH protein expression within the substantia nigra. in contrast, the coadministration of MPTP and L-DOPA did not demonstrate such difference. the striatal levels of dopamine were reduced after MPTP or L-DOPA, with an increased turnover only for the MPTP group. in view of such results, it seems reasonable to suggest that L-DOPA could potentially produce dopaminergic neurotoxicity.en
dc.description.affiliationUniv Fed Santa Catarina, Dept Farmacol, BR-88040900 Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Parana, Dept Farmacol, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurofisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurofisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent259-268
dc.identifierhttp://dx.doi.org/10.1007/978-3-211-92660-4_21
dc.identifier.citationJournal of Neural Transmission-supplement. New York: Springer, n. 73, p. 259-268, 2009.
dc.identifier.doi10.1007/978-3-211-92660-4_21
dc.identifier.issn0303-6995
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31150
dc.identifier.wosWOS:000274225400021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Neural Transmission-supplement
dc.rightsAcesso restrito
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectAnimal modelen
dc.subjectL-DOPAen
dc.subjectMPTPen
dc.subjectNeurotoxicityen
dc.subjectParkinson's diseaseen
dc.subjectTyrosine hydroxylaseen
dc.titleDistinct Effects of Intranigral L-DOPA Infusion in the MPTP Rat Model of Parkinson's Diseaseen
dc.typeArtigo
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