Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Página do item simplificado
dc.contributor.authorCâmara, Niels Olsen Saraiva [UNIFESP]
dc.contributor.authorWilliams Jr., W.w.
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHarvard University Massachusetts General Hospital
dc.contributor.institutionInstituto Israelita de Ensino e Pesquisa Hospital Albert Einstein Unidade de Transplante Renal
dc.date.accessioned2015-06-14T13:39:06Z
dc.date.available2015-06-14T13:39:06Z
dc.date.issued2009-03-01
dc.description.abstractNew strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF) development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, N-acetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital do Rim e Hipertensão
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Instituto de Ciências Biomédicas IV Departamento de Imunologia
dc.description.affiliationHarvard University Massachusetts General Hospital
dc.description.affiliationInstituto Israelita de Ensino e Pesquisa Hospital Albert Einstein Unidade de Transplante Renal
dc.description.affiliationUnifespUNIFESP, EPM, Hospital do Rim e Hipertensão
dc.description.affiliationUnifespUNIFESP, Instituto de Ciências Biomédicas IV Depto. de Imunologia
dc.description.sourceSciELO
dc.format.extent229-236
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300003
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 3, p. 229-236, 2009.
dc.identifier.fileS0100-879X2009000300003.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2009000300003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4911
dc.identifier.wosWOS:000264200100003
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal transplantationen
dc.subjectTubular proteinsen
dc.subjectProximal tubular dysfunctionen
dc.subjectChronic allograft nephropathyen
dc.subjectRetinol binding proteinen
dc.titleProximal tubular dysfunction as an indicator of chronic graft dysfunctionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X2009000300003.pdf
Tamanho:
73.79 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos