Anterior thalamus deep brain stimulation at high current impairs memory in rats

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dc.contributor.authorHamani, Clement [UNIFESP]
dc.contributor.authorDubiela, Francisco Paulino [UNIFESP]
dc.contributor.authorSoares, Juliana C. K. [UNIFESP]
dc.contributor.authorShin, Damian
dc.contributor.authorBittencourt, Simone [UNIFESP]
dc.contributor.authorCovolan, Luciene [UNIFESP]
dc.contributor.authorCarlen, Peter L.
dc.contributor.authorLaxton, Adrian W.
dc.contributor.authorHodaie, Mojgan
dc.contributor.authorStone, Scellig S. D.
dc.contributor.authorHa, Yoon
dc.contributor.authorHutchison, William D.
dc.contributor.authorLozano, Andres M.
dc.contributor.authorMello, Luiz E. [UNIFESP]
dc.contributor.authorOliveira, Maria Gabriela M. [UNIFESP]
dc.contributor.institutionToronto Western Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:25Z
dc.date.available2016-01-24T14:05:25Z
dc.date.issued2010-09-01
dc.description.abstractDeep brain stimulation (DBS) of the anterior thalamic nucleus (AN), an important relay in the circuitry of memory, is currently being proposed as a treatment for epilepsy. Despite the encouraging results with the use of this therapy, potential benefits and adverse effects are yet to be determined. we show that AN stimulation at relatively high current disrupted the acquisition of contextual fear conditioning and impaired performance on a spatial alternating task in rats. This has not been observed at parameters generating a charge density that approximated the one used in clinical practice. At settings that impaired behavior, AN stimulation induced a functional depolarization block nearby the electrode, increased c-Fos expression in cerebral regions projecting to and receiving projections from the AN, and influenced hippocampal activity. This suggests that complex mechanisms might be involved in the effects of AN DBS, including a local target inactivation and the modulation of structures at a distance. Though translating data from animals to humans has to be considered with caution, our study underscores the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of AN DBS. (C) 2010 Elsevier Inc. All rights reserved.en
dc.description.affiliationToronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Neurofisiol, São Paulo, Brazil
dc.description.affiliationToronto Western Hosp, Div Neurol, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Neurofisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent154-162
dc.identifierhttp://dx.doi.org/10.1016/j.expneurol.2010.06.007
dc.identifier.citationExperimental Neurology. San Diego: Academic Press Inc Elsevier Science, v. 225, n. 1, p. 154-162, 2010.
dc.identifier.doi10.1016/j.expneurol.2010.06.007
dc.identifier.issn0014-4886
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32874
dc.identifier.wosWOS:000281339300021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAnterior nucleusen
dc.subjectThalamusen
dc.subjectMemoryen
dc.subjectEpilepsyen
dc.subjectDeep brain stimulationen
dc.subjectHippocampusen
dc.subjectAdverse effectsen
dc.titleAnterior thalamus deep brain stimulation at high current impairs memory in ratsen
dc.typeinfo:eu-repo/semantics/article
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