Characterization of tccP2 carried by atypical enteropathogenic Escherichia coli

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dc.contributor.authorOoka, Tadasuke
dc.contributor.authorVieira, Monica A. M. [UNIFESP]
dc.contributor.authorOgura, Yoshitoshi
dc.contributor.authorBeutin, Lothar
dc.contributor.authorLa Ragione, Roberto
dc.contributor.authorvan Diemen, Pauline M.
dc.contributor.authorStevens, Mark P.
dc.contributor.authorAktan, Ilknur
dc.contributor.authorCawthraw, Shaun
dc.contributor.authorBest, Angus
dc.contributor.authorHernandes, Rodrigo T. [UNIFESP]
dc.contributor.authorKrause, Gladys
dc.contributor.authorGomes, Tania A. T. [UNIFESP]
dc.contributor.authorHayashi, Tetsuya
dc.contributor.authorFrankel, Gad
dc.contributor.institutionUniv London Imperial Coll Sci Technol & Med
dc.contributor.institutionMiyazaki Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBundesinst Risikobewertung
dc.contributor.institutionVet Labs Agcy
dc.date.accessioned2016-01-24T13:48:45Z
dc.date.available2016-01-24T13:48:45Z
dc.date.issued2007-06-01
dc.description.abstractAtypical enteropathogenic Escherichia coli (EPEC) comprise an important group of paediatric pathogens. Atypical EPEC have reservoirs in farm and domestic animals where they can be either commensal or pathogenic; serogroup O26 is dominant in humans and animals. Central to intestinal colonization by EPEC is the translocation of the type III secretion system effector Tir into enterocytes, which following phosphorylation (Tir-Yp) recruits Nck to activate the N-WASP actin signalling cascade. the authors have recently shown that typical EPEC strains, belonging to the EPEC-2 lineage, carry a tir gene encoding Tir-Yp and can also use the alternative TccP2 actin-signalling cascade. the aim of this study was to determine if tccP2 is found in atypical EPEC isolated from human and farm animals. tccP2 was found at a frequency of 41% in non-O26 EPEC isolates and in 82.3% of the O26 strains. TccP2 of human and animal strains show high level of sequence identity. It is shown that most strains carry a tir gene encoding Tir-Yp. in addition the authors identified two new variants of tir genes in EPEC O104:H12 and NT:H19 strains.en
dc.description.affiliationUniv London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England
dc.description.affiliationMiyazaki Univ, Frontier Sci Res Ctr, Div Bioenvironm Sci, Miyazaki, Japan
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationBundesinst Risikobewertung, Natl Referanzlabor Escherichia Coli, Berlin, Germany
dc.description.affiliationVet Labs Agcy, Dept Food & Environm Safety, Surrey, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent126-135
dc.identifierhttp://dx.doi.org/10.1111/j.1574-6968.2007.00707.x
dc.identifier.citationFems Microbiology Letters. Oxford: Blackwell Publishing, v. 271, n. 1, p. 126-135, 2007.
dc.identifier.doi10.1111/j.1574-6968.2007.00707.x
dc.identifier.issn0378-1097
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29769
dc.identifier.wosWOS:000246241500020
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofFems Microbiology Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEPECen
dc.subjectTccPen
dc.subjecttype III secretionen
dc.titleCharacterization of tccP2 carried by atypical enteropathogenic Escherichia colien
dc.typeinfo:eu-repo/semantics/article
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