Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus

dc.contributor.authorSilva, Clovis AA
dc.contributor.authorHallak, Jorge
dc.contributor.authorPasqualotto, Fabio F.
dc.contributor.authorBarba, Mario F.
dc.contributor.authorSaito, Maria I.
dc.contributor.authorKiss, Maria HB
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-18T10:46:08Z
dc.date.available2018-06-18T10:46:08Z
dc.date.issued2002-09-01
dc.description.abstractObjective. To evaluate gonadal function in male adolescents and young men with juvenile onset systemic lupus erythematosus (SLE).Methods. Four young men with SLE underwent clinical and laboratory evaluation, testicular ultrasound, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, and and-sperm antibody determination. The semen analyses were per-formed according to the WHO guidelines and Kruger strict criteria. All patients were asked to provide 3 semen samples over a period of 2 months. A new sample was collected 6 months later.Results. The median disease duration was 6.6 years. The median age at initial ejaculation was 13.5 years. All 4 patients had severe disease with renal involvement (WHO class IV or V). The SLICC/ACR damage index at the time of study entry ranged between 0 and 3. The patients' Tanner stage was P5G5; all reported normal erection and libido. Gonadal evaluation by thorough examination of the genitalia and ultrasound was normal. Anti-sperm antibodies were negative in all patients. Only one patient showed high FSH and LH levels. The initial and final semen evaluations of the 4 patients were abnormal (azoospermia, oligoastenoteratospermia, or teratospermia). One patient was receiving azathioprine and 2 were receiving cyclophosphamide at the time of study entry.Conclusion. Although these patients had normal sexual activity and normal external genitalia, their fertility was decreased based on the sperm abnormalities. Serial semen analyses in larger study populations will be necessary to clarify the degree and duration of sperm abnormalities in male patients with SLE in general.en
dc.description.affiliationUniv Sao Paulo, Pediat Rheumatol Unit, Dept Pediat, Childrens Inst, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Div Urol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2000-2005
dc.identifierhttp://www.jrheum.org/content/29/9/2000
dc.identifier.citationJournal Of Rheumatology. Toronto: J Rheumatol Publ Co, v. 29, n. 9, p. 2000-2005, 2002.
dc.identifier.issn0315-162X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44667
dc.identifier.wosWOS:000177825300030
dc.language.isoeng
dc.publisherJ Rheumatol Publ Co
dc.relation.ispartofJournal Of Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectlupusen
dc.subjectmaleen
dc.subjectgonadalen
dc.subjectsemenen
dc.subjecthormoneen
dc.subjectadolescenten
dc.titleGonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosusen
dc.typeinfo:eu-repo/semantics/article
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