Astaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Model

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dc.citation.issue4
dc.citation.volumev. 16
dc.contributor.authorMano, Camila M.
dc.contributor.authorGuaratini, Thais
dc.contributor.authorCardozo, Karina H. M.
dc.contributor.authorColepicolo, Pio
dc.contributor.authorBechara, Etelvino José Henriques [UNIFESP]
dc.contributor.authorBarros, Marcelo P.
dc.coverageBasel
dc.date.accessioned2020-07-20T16:31:05Z
dc.date.available2020-07-20T16:31:05Z
dc.date.issued2018
dc.description.abstractAstaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a "mitochondrial-targeted" action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6.2 to 8.0), which were challenged by oxidizing/nitrating conditions that mimic the regular and preapoptotic redox environment of active mitochondria. Pre-apoptotic conditions were created by oxidized/nitr(osyl) ated cytochrome c and resulted in the highest levels of lipoperoxidation in both PCL and PCPGLs (pH 7.4). ASTA was less protective at acidic conditions, especially in anionic PCPGLs. Our data demonstrated the ability of ASTA to hamper oxidative and nitrative events that lead to cytochrome c-peroxidase apoptosis and lipid peroxidation, although its efficiency changes with pH and lipid composition of membranes.en
dc.description.affiliationUniv Sao Paulo IQUSP, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Cruzeiro Sul, ICAFE, BR-01506000 Sao Paulo, SP, Brazil
dc.description.affiliationSuperintendencia Policia Tecn Cient, BR-05507060 Sao Paulo, SP, Brazil
dc.description.affiliationLychnoflora Pesquisa & Dev Prod Nat LTDA, BR-14030090 Ribeirao Preto, SP, Brazil
dc.description.affiliationGrp Fleury, BR-04344070 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, UNIFESP, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Sao Paulo IQUSP, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationCSIC, IATA, Dept Ciencia Alimentos, Calle Catedrat Agustin Escardino 7, Paterna 46980, Spain
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, UNIFESP, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP
dc.description.sponsorshipBPE fellowship)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (Bolsa Produtividade em Pesquisa, Nivel 2, CNPq, Brazil)
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnologia para el Desarollo (CYTED
dc.description.sponsorshipRed iberoamericana para el estudio de nuevos carotenoides bioactivos como ingredientes de alimentos, Spain)
dc.description.sponsorshipIDFAPESP: 017/06032-2
dc.description.sponsorshipIDCNPq: 304663/2015-8
dc.description.sponsorshipIDRIENCBI: 112RT0445
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/md16040126
dc.identifier.citationMarine Drugs. Basel, v. 16, n. 4, 2018.
dc.identifier.doi10.3390/md16040126
dc.identifier.fileWOS000431068000028.pdf
dc.identifier.issn1660-3397
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55696
dc.identifier.wosWOS:000431068000028
dc.language.isoeng
dc.publisherMdpi
dc.relation.ispartofMarine Drugs
dc.rightsAcesso aberto
dc.subjectmitochondriaen
dc.subjectmembraneen
dc.subjectlipid peroxidationen
dc.subjectapoptosisen
dc.subjectcarotenoiden
dc.subjectantioxidanten
dc.subjectliposomeen
dc.subjectoxidative stressen
dc.titleAstaxanthin Restrains Nitrative-Oxidative Peroxidation in Mitochondrial-Mimetic Liposomes: A Pre-Apoptosis Modelen
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