Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase's

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dc.contributor.authorKumar, Prabhanshu
dc.contributor.authorChand, Subhash
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.date.accessioned2019-01-21T10:29:44Z
dc.date.available2019-01-21T10:29:44Z
dc.date.issued2016
dc.description.abstractContent: Quercetin uptake by erythrocytes is rapid. The sodium-hydrogen exchanger (NHE) is a secondary active transporter, regulating intracellular pH, Na+ concentration and cell volume. Objective: The aim of present study was to investigate NHE as a function of human age and effect of quercetin on its activity. The NHE activity was correlated with erythrocytes ATPases. Materials and methods: We analyzed normal, healthy subjects of both sexes (20-82 years). NHE activity was estimated in terms of amiloride-sensitive H+-efflux from acid-loaded cells. Results: A significant age-dependent increase in NHE activity was observed during aging in humans. Concentration (10(-3) M to 10(-8) M)-dependent in vitro treatment with quercetin causes inhibition of NHE activity. The Na+/K+ -ATPase (r = 0.8882) and Ca2+-ATPase (r = 0.9540) activities positively correlated with it. Discussion and conclusion: The present data show an additional mechanism where dietary flavonoids may exerts beneficial effect during aging.en
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida 201303, India
dc.description.affiliationIndian Inst Technol, Dept Biochem Engn & Biotechnol, Delhi, India
dc.description.affiliationUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipcoordination of Improvement of Higher Education Personnel (CAPES), National Counsel of Technological and Scientific Development (CNPq), Brazil
dc.format.extent141-147
dc.identifierhttps://doi.org/10.3109/13813455.2016.1150299
dc.identifier.citationArchives Of Physiology And Biochemistry. Abingdon, v. 122, n. 3, p. 141-147, 2016.
dc.identifier.doi10.3109/13813455.2016.1150299
dc.identifier.issn1381-3455
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49357
dc.identifier.wosWOS:000386832300005
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofArchives Of Physiology And Biochemistry
dc.rightsAcesso restrito
dc.subjectAgingen
dc.subjectCa2+-Atpaseen
dc.subjectNa+/H+ Exchangeren
dc.subjectNa+/K+-Atpaseen
dc.subjectQuercetinNa+/H+ Exchangeren
dc.subjectEnzyme-Activitiesen
dc.subjectAcidic Phen
dc.subjectHuman Ageen
dc.subjectCellsen
dc.subjectTransporten
dc.subjectCanceren
dc.subjectGlutathioneen
dc.subjectHomeostasisen
dc.subjectInhibitionen
dc.titleQuercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase'sen
dc.typeArtigo
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