Secondary hyperparathyroidism and its relationship with sarcopenia in elderly women

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dc.contributor.authorGenaro, Patricia de Souza
dc.contributor.authorPinheiro, Marcelo de Medeiros [UNIFESP]
dc.contributor.authorSzejnfeld, Vera Lucia [UNIFESP]
dc.contributor.authorMartini, Ligia Araujo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:10Z
dc.date.available2016-01-24T14:40:10Z
dc.date.issued2015-03-01
dc.description.abstractLow dietary intake of calcium and poor vitamin D status during aging can result in mild secondary hyperparathyroidism, which may be associated with low muscle mass and reduced strength in the elderly. the aim of this study was to investigate whether low vitamin D, high parathormone (PTH), or both, are associated with sarcopenia. A total of 105 women, 35 with sarcopenia and 70 without sarcopenia, were enrolled in the present study. Body composition measurements were performed by DXA and sarcopenia was defined as skeletal muscle mass index < 5.45 kg/m(2) and grip strength lower than 20 kg. Three-day dietary records were taken and adjustments for energy intake made. the estimated average requirement (EAR) method was adopted as a cut-off point for estimating the prevalence of inadequate intake. Serum total calcium, phosphorus, creatinine, intact PTH, and 25(OH) D were measured. Only 1% of the patients met the daily adequate intake for vitamin D and 11% met the daily adequate intake for calcium. Notably, the prevalence of sarcopenia was higher in hyperparathyroidism (25(OH)D < 20 ng/mL and PTH > 65 pg/dL) than in the absence of hyperparathyroidism (41.2 vs 16.2%, respectively; p = 0.046). the odds ratio for sarcopenia in hyperparathyroidism cases was 6.81 (95% CI 1.29-35.9) compared with participants who had low PTH and a high 25(OH) D concentration. the present study showed that vitamin D insufficiency associated with secondary hyperparathyroidism increased the risk of sarcopenia, suggesting that the suppression of hyperparathyroidism by ensuring adequate calcium and vitamin D intake should be considered in interventional studies to confirm potential benefits. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Rheumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Rheumatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 03/06238-7
dc.description.sponsorshipIDFAPESP: 03/10314-0
dc.description.sponsorshipIDCNPq: 471213/2008-0
dc.format.extent349-353
dc.identifierhttp://dx.doi.org/10.1016/j.archger.2015.01.005
dc.identifier.citationArchives of Gerontology and Geriatrics. Clare: Elsevier B.V., v. 60, n. 2, p. 349-353, 2015.
dc.identifier.doi10.1016/j.archger.2015.01.005
dc.identifier.issn0167-4943
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38825
dc.identifier.wosWOS:000349695000018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofArchives of Gerontology and Geriatrics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectVitamin D deficiencyen
dc.subjectParathormoneen
dc.subjectMuscle massen
dc.subjectElderlyen
dc.subjectBody compositionen
dc.titleSecondary hyperparathyroidism and its relationship with sarcopenia in elderly womenen
dc.typeinfo:eu-repo/semantics/article
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