Dietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brain

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dc.contributor.authorDalPai, Janise [UNIFESP]
dc.contributor.authorBorges, Andrea Aurélio [UNIFESP]
dc.contributor.authorGrassl, Christian [UNIFESP]
dc.contributor.authorFavero Filho, Luiz Antonio [UNIFESP]
dc.contributor.authorXavier, Gilberto Fernando [UNIFESP]
dc.contributor.authorJunqueira, Virginia Berlanga Campos [UNIFESP]
dc.contributor.authorLopes, Antonio Carlos [UNIFESP]
dc.contributor.authorCoimbra, Cicero Galli [UNIFESP]
dc.contributor.authorSinigaglia-Coimbra, Rita [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:05:16Z
dc.date.available2018-06-15T17:05:16Z
dc.date.issued2007-11-01
dc.description.abstractVitamin B2 deficiency associated with normal dietary intake has been reported inpatients with Parkinson disease (PD), suggesting impaired absorption of this micronutrient. Elevated red meat consumption was thought to contribute as a triggering factor, as the catabolism of hemin (a neurotoxic substance) requires vitamin B2 (Coimbra &Junqueira, 2003). This study tested this hypothesis by verifying the effects of dietary riboflavin restriction associated with hemin administration on rat brain. After 8 months of riboflavin restriction, riboflavin deficiency with or without oral administration of hemin (assessed by erythrocyte glutathion ereductase activity) did not impair motor function or spatial learning; neither altered the volume of substantia nigra or brain concentrations of total glutathione. Partial dietary restriction of riboflavin may failed to induce oxidative stress in the rat brain and dopaminergic degeneration in the rat substantia nigra as suggested to occur in humans by Coimbra & Junqueita, (2003), possibly due to an intact mechanism of nutritional privilege that preserves riboflavin content in the normal rat brain during deficiency states. Contrastingly, polymorphic enzymes or receptors involved in the human cellular uptake of ribofiavin may conceivably impair the transport of this micronutrient not only through the intestinal wall and renal tubules, but also in the brain of PD patients, there by annulling the nutritional privilege of the nervous system.en
dc.description.affiliationUniv Fed Sao Paulo, Lab Clin & Expt Physiopathol, Dept Med, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morphol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, COLSAN, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Ctr Electron Microscopy, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Lab Clin & Expt Physiopathol, Dept Med, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Morphol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, COLSAN, BR-04039032 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Ctr Electron Microscopy, BR-04039032 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent149-155
dc.identifierhttp://ctnr.newcenturyhealthpublishers.com/about/pdf/ctnrv5p149_156.pdf
dc.identifier.citationCurrent Topics In Nutraceutical Research. Coppell: New Century Health Publishers, Llc, v. 5, n. 4, p. 149-155, 2007.
dc.identifier.issn1540-7535
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43477
dc.identifier.wosWOS:000255670800002
dc.language.isoeng
dc.publisherNew Century Health Publishers, Llc
dc.relation.ispartofCurrent Topics In Nutraceutical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFADen
dc.subjectglutathioneen
dc.subjectheminen
dc.subjectParkinson's diseaseen
dc.subjectriboflavinen
dc.subjectsubstantia nigraen
dc.titleDietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brainen
dc.typeinfo:eu-repo/semantics/article
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