A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity

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dc.contributor.authorAndrade, Giuliana Paiva Viana de
dc.contributor.authorLima, Marcelo Andrade de [UNIFESP]
dc.contributor.authorSouza Junior, Airton Araujo de [UNIFESP]
dc.contributor.authorFareed, Jawed
dc.contributor.authorHoppensteadt, Debra A.
dc.contributor.authorSantos, Elizeu Antunes dos
dc.contributor.authorChavante, Suely Ferreira
dc.contributor.authorOliveira, Fernanda Wanderley de
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Liverpool
dc.contributor.institutionInst Fed Rio Grande Norte
dc.contributor.institutionLoyola Med Sch
dc.date.accessioned2016-01-24T14:31:34Z
dc.date.available2016-01-24T14:31:34Z
dc.date.issued2013-04-15
dc.description.abstractA natural heparin-like compound isolated from the crab Goniopsis cruentata was structurally characterized and its anticoagulant and hemorrhagic activities were determined. Enzymatic and nuclear magnetic resonance analysis revealed that its structure is rich in disulfated disaccharides, possessing significant amounts of 2-O-sulfated-beta-D-glucuronic acid units. Furthermore, low amounts of trisulfated disaccharide units containing 2-O-sulfated-alpha-L-iduronic acid were detected, when compared to mammalian heparin. in addition, this heparin-like structure showed negligible in vitro anticoagulant activity and low bleeding potency, facts that make it a suitable candidate for the development of structure-driven, heparin based therapeutic agents with fewer undesirable effects. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniv Liverpool, Dept Struct & Chem Biol, Liverpool L69 7ZB, Merseyside, England
dc.description.affiliationInst Fed Rio Grande Norte, Dept Biol, Natal, RN, Brazil
dc.description.affiliationLoyola Med Sch, Dept Pathol, Maywood, IL USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent647-654
dc.identifierhttps://dx.doi.org/10.1016/j.carbpol.2013.01.069
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 94, n. 1, p. 647-654, 2013.
dc.identifier.doi10.1016/j.carbpol.2013.01.069
dc.identifier.fileWOS000317888500085.pdf
dc.identifier.issn0144-8617
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/36206
dc.identifier.wosWOS:000317888500085
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHeparinen
dc.subjectHeparan sulfateen
dc.subjectNuclear magnetic resonanceen
dc.subjectHeparinasesen
dc.subjectAnticoagulant activityen
dc.subjectHemorrhagic effecten
dc.titleA heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activityen
dc.typeinfo:eu-repo/semantics/article
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