Prognostic value of GRIM-19, NF-kappa B and IKK2 in patients with high-grade serous ovarian cancer

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dc.citation.issue2
dc.citation.volume214
dc.contributor.authorIlelis, Felipe
dc.contributor.authordo Amaral, Nayra Soares
dc.contributor.authorAlves, Mariana Rezende
dc.contributor.authorBalieiro Anastacio da Costa, Alexandre Andre
dc.contributor.authorCalsavara, Vinicius Fernando
dc.contributor.authorLordello, Leonardo
dc.contributor.authorDe Brot, Louise
dc.contributor.authorSoares, Fernando Augusto
dc.contributor.authorRodrigues, Iara Sant'Ana
dc.contributor.authorRocha, Rafael Malagoli [UNIFESP]
dc.coverageJena
dc.date.accessioned2020-07-08T13:09:44Z
dc.date.available2020-07-08T13:09:44Z
dc.date.issued2018
dc.description.abstractAims: High grade serous carcinoma (HGSC) is an aggressive tumour, and most patients relapse after treatment, acquiring resistance to platinum-based chemotherapy. One of the resistance mechanisms proposed is apoptosis evasion triggered by drug-related cytotoxic effect in the cell. In this context, this study aims to evaluate the protein expression of GRIM-19, NF-kappa B and IKK2, their association with chemotherapy response and to determine their prognostic values in HGSC. & para;& para;Methods: GRIM-19, NF-kappa B and IKK2 expression was evaluated by immunohistochemistry (IHC) in 71 patients with HGSC selected between 2003 and 2013, whose underwent primary debulking surgery with complete cytoreduction. Protein expression was analyzed in relation to platinum response groups, tumour progression, clinicopathological data and survival. & para;& paraen
dc.description.abstractResults: Positive IKK2 expression was related to resistance (p = 0.011), shorter disease-free survival (p = 0.001) and overall survival (p = 0.026) and was also a risk factor for relapse (p = 0.002) and death (p = 0.032). The association between IKK2 and NF-kappa B positivity predicted a subgroup with shorter overall survival (p = 0.004), disease-free survival (p = 0.003) and resistance to platinum-based chemotherapy (p = 0.036). NF-kappa B positivity was associated with worse overall survival (p = 0.005) and disease-free survival (p = 0.027) and was a positive predictor for relapse (p = 0.032) and death (p = 0.008). Higher expression of GRIM-19 was associated with higher disease-free survival (p = 0.039) and was a negative predictor for relapse (p = 0.046). & para;& para;Conclusions: GRIM-19 is a potential predictor of prognosis and disease recurrence in HGSC. IKK2 and NF-kappa B are related to poor prognosis and are potential predictors of response to platinum-based chemotherapy in HGSC. IHC analyses of GRIM19, IKK2 and NF-kappa B may be important in the attempt to provide prognostic values for relapse and response to treatment in patients with HGSC.en
dc.description.affiliationAC Camargo Canc Ctr, Dept Invest Pathol, Lab Mol Morphol, Sao Paulo, SP, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Med Oncol, Sao Paulo, SP, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Epidemiol & Stat, Sao Paulo, SP, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynaecol, Lab Mol Gynaecol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynaecol, Lab Mol Gynaecol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipCoordination for the Improvement of Higher Educational Personnel (CAPES)
dc.format.extent187-194
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2017.12.002
dc.identifier.citationPathology Research And Practice. Jena, v. 214, n. 2, p. 187-194, 2018.
dc.identifier.doi10.1016/j.prp.2017.12.002
dc.identifier.issn0344-0338
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54163
dc.identifier.wosWOS:000429085800002
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofPathology Research And Practice
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectImmunohistochemistryen
dc.subjectSerous cystadenocarcinomaen
dc.subjectOvarian neoplasmsen
dc.subjectPlatinumen
dc.subjectRecurrenceen
dc.subjectPrognosisen
dc.titlePrognostic value of GRIM-19, NF-kappa B and IKK2 in patients with high-grade serous ovarian canceren
dc.typeinfo:eu-repo/semantics/article
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