Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder

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dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorSantos, Camila M. [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorCunha, Graccielle R. [UNIFESP]
dc.contributor.authorNoto, Mariane N. [UNIFESP]
dc.contributor.authorPedrini, Mariana [UNIFESP]
dc.contributor.authorZeni-Graiff, Maiara [UNIFESP]
dc.contributor.authorCordeiro, Quirino
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.date.accessioned2019-08-19T11:48:42Z
dc.date.available2019-08-19T11:48:42Z
dc.date.issued2017
dc.description.abstractAimThis study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relation between copeptin and metabolic parameters. MethodsWe measured plasma levels of copeptin in individuals with BD (n=55) and healthy controls (n=21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured. Insulin resistance and -cell function in basal state were calculated from fasting plasma glucose and C-peptide using the HOMA2 calculator. Impaired glucose metabolism was defined as pre-diabetes or type 2 diabetes mellitus. Copeptin, adiponectin, and leptin plasma levels were determined by enzyme-linked immunosorbent assay. ResultsPlasma copeptin levels were lower in individuals with BD, relative to healthy controls (P<0.001). There were significant interactions between BD and plasma copeptin on -cell function (rate ratio [RR]=1.048en
dc.description.abstractP=0.030) and on leptin levels (RR=1.087en
dc.description.abstractP=0.012), indicating that there was a positive correlation between these markers in the BD group, but a negative one in healthy controls. Finally, in individuals with BD only, the association between -cell function, body mass index (RR=1.007en
dc.description.abstractP<0.001), and insulin resistance (RR=1.001en
dc.description.abstractP=0.037) was moderated by copeptin levels. ConclusionCopeptin levels were lower in individuals with BD than in healthy controls. There were differential associations between copeptin and metabolic parameters within the BD and healthy control subgroups, suggesting an association between abnormal copeptin and metabolic dysregulation only in the BD population.en
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Psychiat, Reserach Grp Behav & Mol Neurosci Bipolar Disorde, São Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, MDPU, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniv Tubingen, Dept Psychiat Clin Psychiat & Psychotherapy, Tubingen, Germany
dc.description.affiliationVila Maria Outpatient Clin, São Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Psychiat, Reserach Grp Behav & Mol Neurosci Bipolar Disorde, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.format.extent624-636
dc.identifierhttp://dx.doi.org/10.1111/pcn.12535
dc.identifier.citationPsychiatry And Clinical Neurosciences. Hoboken, v. 71, n. 9, p. 624-636, 2017.
dc.identifier.doi10.1111/pcn.12535
dc.identifier.issn1323-1316
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51326
dc.identifier.wosWOS:000409188900004
dc.language.isoeng
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbipolar disorderen
dc.subjectcopeptinen
dc.subjectinsulin resistanceen
dc.subjectmetabolismen
dc.subjectvasopressinen
dc.titlePlasma copeptin and metabolic dysfunction in individuals with bipolar disorderen
dc.typeinfo:eu-repo/semantics/article
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