Pruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: A histopathological and immunohistochemical comparative study

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dc.contributor.authorJunqueira Magalhaes Afonso, Joao Paulo [UNIFESP]
dc.contributor.authorTomimori, Jane [UNIFESP]
dc.contributor.authorMichalany, Nilceo Schwery [UNIFESP]
dc.contributor.authorNonogaki, Suely
dc.contributor.authorPorro, Adriana Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAdolfo Lutz Inst
dc.date.accessioned2016-01-24T14:27:31Z
dc.date.available2016-01-24T14:27:31Z
dc.date.issued2012-08-01
dc.description.abstractBackground: Among the papular-pruriginous dermatoses related to human immunodeficiency (HIV) infection, two entities remain poorly differentiated leading to confusion in their diagnosis: HIV-related pruritic papular eruption (HIV-PPE or prurigo) and eosinophilic folliculitis (HIV-EF).Objective: To establish histopathological and immunohistochemical parameters to differentiate between two conditions associated with HIV infection, the pruritic papular eruption (HIV-PPE) and eosinophilic folliculitis (HIV-EF).Methods: Clinically typical HIV-PPE (18 cases) and HIV-EF (10 cases) cases were compared with each other in terms of the following topics: clinical and laboratory features (gender, age, CD4+ cell and eosinophil count), histopathological features (hematoxylin-eosin and toluidine blue staining) and immunohistochemical features (anti-CD1a, anti-CD4, anti-CD7, anti-CD8, anti-CD15, anti-CD20, anti-CD30, antiCD68/macrophage and anti-S-100 reactions).Results: Among the HIV-EF patients, we found an intense perivascular and diffuse inflammatory infiltration compared with those patients with HIV-PPE. the tissue mast cell count by toluidine staining was higher in the HIV-EF patients, who also presented higher expression levels of CD15 (for eosinophils), CD4 (T helper), and CD7 (pan-T lymphocytes) than the HIV-PPE patients.Limitations: Only quantitative differences and not qualitative differences were found.Conclusions: These data indicate that HIV-related PPE and EF could possibly be differentiated by histopathological and immunohistochemical findings in addition to clinical characteristics. in fact, these two inflammatory manifestations could be within the spectrum of the same disease because only quantitative, and not qualitative, differences were found. (J Am Acad Dermatol 2012;67:269-75.)en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationAdolfo Lutz Inst, Div Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent269-275
dc.identifierhttp://dx.doi.org/10.1016/j.jaad.2011.11.923
dc.identifier.citationJournal of the American Academy of Dermatology. New York: Mosby-Elsevier, v. 67, n. 2, p. 269-275, 2012.
dc.identifier.doi10.1016/j.jaad.2011.11.923
dc.identifier.issn0190-9622
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35135
dc.identifier.wosWOS:000306368600023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the American Academy of Dermatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecteosinophilic folliculitisen
dc.subjecthistopathologicalen
dc.subjectHIVen
dc.subjectimmunohistochemicalen
dc.subjectprurigoen
dc.subjectpruritic papular eruptionen
dc.titlePruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: A histopathological and immunohistochemical comparative studyen
dc.typeinfo:eu-repo/semantics/article
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