Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

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dc.contributor.authorSouza, Femanda G. de
dc.contributor.authorRodrigues, Mayra D. B.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorNobrega, Jose N.
dc.contributor.authorD'Almeida, Vania
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Addict & Mental Hlth
dc.date.accessioned2016-01-24T12:41:31Z
dc.date.available2016-01-24T12:41:31Z
dc.date.issued2006-10-01
dc.description.abstractHomocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin 136, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). in general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats.These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, Brazil
dc.description.affiliationCtr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent400-407
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2006.09.008
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 85, n. 2, p. 400-407, 2006.
dc.identifier.doi10.1016/j.pbb.2006.09.008
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29193
dc.identifier.wosWOS:000243621800016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecthomocysteine metabolismen
dc.subjectacute stressen
dc.subjectpsychological stressen
dc.subjectoxidative stressen
dc.subjectfemale ratsen
dc.titleAcute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female ratsen
dc.typeinfo:eu-repo/semantics/article
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