Incidence, Risk Factors, and Morbidity of Acquired Postnatal Cytomegalovirus Infection Among Preterm Infants Fed Maternal Milk in a Highly Seropositive Population

Página do item simplificado
dc.citation.issue7
dc.citation.volume63
dc.contributor.authorMartins-Celini, Fabia Pereira
dc.contributor.authorYamamoto, Aparecida Yulie
dc.contributor.authorPassos, Debora Manzione
dc.contributor.authordo Nascimento, Suely Dornellas
dc.contributor.authorLima, Edineia Vaciloto
dc.contributor.authorDi Giovanni, Celia Mara
dc.contributor.authorSevilla Quadrado, Ellen Regina
dc.contributor.authorBarta, Roberta
dc.contributor.authorAragon, Davi Casale
dc.contributor.authordo Prado, Seila Israel
dc.contributor.authorAlmeida, Maria Fernanda Branco de [UNIFESP]
dc.contributor.authorMussi-Pinhata, Marisa Marcia
dc.coverageCary
dc.date.accessioned2020-07-31T12:47:40Z
dc.date.available2020-07-31T12:47:40Z
dc.date.issued2016
dc.description.abstractPreterm infants born to mothers with high cytomegalovirus (CMV) seroprevalence are as frequently infected as those born to mothers with lower seroprevalence. CMV infection contributes to an uneven clinical course, severe stages of retinopathy of prematurity (ROP), and even death.Methods.aEuro integral A cohort of 188 a parts per thousand currency sign30-week-old infants was monitored from admission to discharge. CMV-DNA, hematology, liver enzymes, neutralizing antibodies, and CMV-DNA-lactia were tested periodically. Results.aEuro integral Mothers of 157 infants (83.5%) were CMV-seropositive. A total of 24/157 (15.3%) infants became infected (95% confidence interval [CI], 9.8-22.6), particularly those of lower gestational age (GAen
dc.description.abstractrelative risk [RR], 2.32en
dc.description.abstract95% CI, 1.01-5.34 for 23-26 weeks). Low (< 1:64) neutralizing antibody titers were similarly detected in CMV-infected and uninfected infants. Mean DNA-lactia in mothers was higher in CMV-infected than in uninfected infants (5.34 log vs 4.60 log). Clinical findings suggestive of CMV disease were similar in CMV-infected (50.0%) and CMV-uninfected (51.1%) infants. Although transitory, > 2 laboratory test abnormalities occurred more frequently among CMV-infected (39.1%) than CMV-uninfected (2.1%) infants. More severe stages of retinopathy of prematurity (ROP) were found among CMV-infected infants (adjusted RR, 2.51en
dc.description.abstract95% CI, 1.07-5.91). Although deaths were more frequent among infected infants, none of the deaths could be directly attributed to CMV. Conclusions.aEuro integral Postnatal CMV infection acquired by exposure to raw maternal milk is very frequent among extremely premature newborns, being facilitated by high DNA-lactia and lower GA, regardless of maternally acquired neutralizing antibody levels. The association with advanced stages of ROP is a concern and needs to be further explored in larger studies.en
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Sch Med, Dept Pediat, BR-14048900 Sao Paulo, Brazil
dc.description.affiliationPro Matre Paulista & Santa Joana Hosp Matern, Neonatol Grp, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Pediatrics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2007/07315-6
dc.format.extent929-936
dc.identifierhttp://dx.doi.org/10.1093/cid/ciw394
dc.identifier.citationClinical Infectious Diseases. Cary, v. 63, n. 7, p. 929-936, 2016.
dc.identifier.doi10.1093/cid/ciw394
dc.identifier.issn1058-4838
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56983
dc.identifier.wosWOS:000386041100019
dc.language.isoeng
dc.publisherOxford Univ Press Inc
dc.relation.ispartofClinical Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcytomegalovirusen
dc.subjecthuman milken
dc.subjectpostnatal infectionen
dc.subjectprematurityen
dc.titleIncidence, Risk Factors, and Morbidity of Acquired Postnatal Cytomegalovirus Infection Among Preterm Infants Fed Maternal Milk in a Highly Seropositive Populationen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos