Bovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animals

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dc.contributor.authorLindsey, Charles Julian [UNIFESP]
dc.contributor.authorAlmeida, Marcos Eduardo de [UNIFESP]
dc.contributor.authorVicari, Camilo Alfredo Faigle [UNIFESP]
dc.contributor.authorCarvalho, Claudemir de
dc.contributor.authorYaguiu, Andrea
dc.contributor.authorFreitas, Antonio Carlos de
dc.contributor.authorBeçak, Willy
dc.contributor.authorStocco, Rita de Cassia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.date.accessioned2018-06-15T17:30:21Z
dc.date.available2018-06-15T17:30:21Z
dc.date.issued2009-01-01
dc.description.abstractPapillomavirus infection in bovines is associated with cutaneous papillomatosis on the hide, udders and other epithelial tissues, as well as in oral respiratory, alimentary and urinary tract mucosa. Bovine papillomavirus (BPV) is also considered the etiological agent of esophageal tumors and the malignant bladder tumors that characterize the clinical condition associated with chronic enzootic hematuria. After infective viral DNA was found in cattle blood and BPV1, 2 and 4 DNA in cattle reproductive and embryonic tissues, we looked for and found BPV DNA in blood, milk, urine, seminal fluid, and spermatozoa of BPV-infected animals. Peripheral blood lymphocyte cultures from BPV-infected animals had high rates of chromosome aberrations, including radial rearrangements that signal oncogenic potential and viral interaction with telomeric regions. The finding of BPV DNA in body fluids and tissues other than the epithelium demonstrates co-infection of other tissues or cell types by papillomavirus and shows the potential role of lymphocytes, seminal fluid and spermatozoa in BPV transmission. Our findings reinforce a peremptory need for prophylactic and therapeutic instruments to curtail this disease in bovine livestock.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.affiliationInst Butantan, Genet Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco, Dept Genet, Recife, PE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent310-318
dc.identifierhttps://dx.doi.org/10.4238/vol8-1gmr573
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 8, n. 1, p. 310-318, 2009.
dc.identifier.doi10.4238/vol8-1gmr573
dc.identifier.fileWOS000265578600031.pdf
dc.identifier.issn1676-5680
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/43722
dc.identifier.wosWOS:000265578600031
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBovine papillomavirusen
dc.subjectBlooden
dc.subjectMilken
dc.subjectUrineen
dc.subjectSemenen
dc.subjectSpermatozoaen
dc.titleBovine papillomavirus DNA in milk, blood, urine, semen, and spermatozoa of bovine papillomavirus-infected animalsen
dc.typeinfo:eu-repo/semantics/article
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