Lipid profiling of follicular fluid from women undergoing IVF: Young poor ovarian responders versus normal responders

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dc.contributor.authorCataldi, Thais [UNIFESP]
dc.contributor.authorCordeiro, Fernanda Bertuccez [UNIFESP]
dc.contributor.authorTeixeira da Costa, Livia Do Vale [UNIFESP]
dc.contributor.authorPilau, Eduardo Jorge
dc.contributor.authorFerreira, Christina Ramires
dc.contributor.authorGozzo, Fabio Cesar
dc.contributor.authorEberlin, Marcos Nogueira
dc.contributor.authorBertolla, Ricardo Pimenta [UNIFESP]
dc.contributor.authorCedenho, Agnaldo Pereira [UNIFESP]
dc.contributor.authorLo Turco, Edson Guimaraes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionJardim Univ Maringa
dc.date.accessioned2016-01-24T14:31:07Z
dc.date.available2016-01-24T14:31:07Z
dc.date.issued2013-01-01
dc.description.abstractThis study identified possible lipid biomarkers in follicular fluid from women with poor ovarian response. These biomarkers indicate pathophysiological pathways and have potential diagnostic applications. An observational case-control study of young women undergoing ovarian stimulation for in-vitro fertilization was conducted. the participants were categorized into a poor ovarian response group and a normal ovarian response to stimulation group. All of the women underwent the same ovarian stimulation protocol, and follicular fluid was collected after ovarian aspiration. Analyses were performed using matrix-assisted laser desorption/ionization mass spectrometry. Principal component analysis and Volcano plots were used to describe follicular fluid classification models based on the lipid profiles. A total of 10 lipids were differentially expressed between the study and control groups. of these lipid ions, three belonged to the phosphatidylcholine subclass and were present in higher concentrations in the control group. the other seven differential lipids were present in the study group and classified into four lipid subclasses: phosphatidylethanolamines, phosphatidylglycerols, phosphatidylinositols, and diacylglycerols. These distinctive lipids may be involved in hormonal responses and oocyte development processes and may be useful as biomarkers for therapeutic intervention in women with poor ovarian response.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, Div Urol, Human Reprod Sect, BR-05012000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Chem, Dalton Mass Spectrometry Lab, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, Campinas, SP, Brazil
dc.description.affiliationJardim Univ Maringa, Univ Maringa, Dept Chem, Maringa, PR, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, Div Urol, Human Reprod Sect, BR-05012000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent269-277
dc.identifierhttp://dx.doi.org/10.3109/14647273.2013.852255
dc.identifier.citationHuman Fertility. New York: Informa Healthcare, v. 16, n. 4, p. 269-277, 2013.
dc.identifier.doi10.3109/14647273.2013.852255
dc.identifier.issn1464-7273
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35860
dc.identifier.wosWOS:000328283000008
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofHuman Fertility
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectPoor ovarian responseen
dc.subjectin-vitro fertilizationen
dc.subjectfollicular fluiden
dc.subjectlipidomicsen
dc.subjectMALDI-MSen
dc.titleLipid profiling of follicular fluid from women undergoing IVF: Young poor ovarian responders versus normal respondersen
dc.typeinfo:eu-repo/semantics/article
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