Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat

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dc.contributor.authorSatake, Susan [UNIFESP]
dc.contributor.authorYamada, Karen Yukie [UNIFESP]
dc.contributor.authorMelo, Liana Lins [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:55Z
dc.date.available2016-01-24T14:17:55Z
dc.date.issued2012-02-10
dc.description.abstractPrepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. the inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. the activation of the IC by the acoustic prepulse reduces startle magnitude. the aim of this study was to elucidate the role of DA transmission of the IC on the development of acoustic PPI. Bilateral microinjections of apomorphine (9.0 mu g/0.5 mu L) an agonist of D-2 receptors, into the IC disrupted PPI while microinjections of haloperidol (0.5 mu g/0.5 mu L), an antagonist of D-2 receptors, into this structure did not alter PPI. These results suggest that dopamine-mediated mechanisms of the IC are involved in the expression of PPI in rodents. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T14:17:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-10. Added 1 bitstream(s) on 2016-01-31T13:35:40Z : No. of bitstreams: 1 WOS000301097100013.pdf: 496889 bytes, checksum: 7e3383d9664a91d62d76ab35879c98bb (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 09/05703-4pt
dc.description.sponsorshipIDFAPESP: 09/07347-0pt
dc.description.sponsorshipIDFAPESP: 09/07278-9pt
dc.format.extent60-63
dc.identifierhttps://dx.doi.org/10.1016/j.neulet.2011.12.052
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 509, n. 1, p. 60-63, 2012.
dc.identifier.doi10.1016/j.neulet.2011.12.052
dc.identifier.fileWOS000301097100013.pdf
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34622
dc.identifier.wosWOS:000301097100013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectApomorphineen
dc.subjectHaloperidolen
dc.subjectInferior colliculusen
dc.subjectPrepulse inhibitionen
dc.subjectRaten
dc.subjectSchizophreniaen
dc.titleEffects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in raten
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