Chemokine production and leukocyte recruitment to the lungs of Paracoccidioides brasiliensis-infected mice is modulated by interferon-gamma

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dc.contributor.authorSouto, Janeusa T.
dc.contributor.authorAliberti, Júlio C.
dc.contributor.authorCampanelli, Ana P.
dc.contributor.authorLivonesi, Márcia C.
dc.contributor.authorMaffei, Cláudia ML
dc.contributor.authorFerreira, Beatriz R.
dc.contributor.authorTravassos, Luiz R. [UNIFESP]
dc.contributor.authorMartinez, Roberto
dc.contributor.authorRossi, Marcos A.
dc.contributor.authorSilva, João S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande Norte
dc.contributor.institutionNIAID
dc.date.accessioned2016-01-24T12:33:57Z
dc.date.available2016-01-24T12:33:57Z
dc.date.issued2003-08-01
dc.description.abstractChemokines and chemokine receptors play a role in cell recruitment during granulomatous inflammatory reactions. Here, we evaluated the expression of chemokines and chemokine receptors and their regulation by IFN-gamma in the course of Paracoccidioides brasiliensis (Pb) infection in mice. We found an association between KC and MEP-1alpha (CCL3) production and neutrophil infiltration in the lungs of Pb-infected mice during the early acute phase of infection. High levels of RANTES/CCL5, MCP-1/CCL2, EP-10/CXCL10, and Mig/CXCL9 simultaneously with mononuclear cell infiltration in the lungs was found. in the absence of IFN-gamma (GKO mice) we observed increased production of KC and MIP-1alpha and chronic neutrophilia. Moreover, we found a change in the chemokine receptor profiles expressed by wild-type (WT) versus GKO animals. Increased expression of CXCR3 and CCR5, and low levels of CCR3 and CCR4 were observed in the lungs of Pb-infected WT mice, whereas the opposite effect was observed in the lungs of GKO mice. Con sistent with these results, infected cells from WT mice preferentially migrated in response to IP-10 (CXCR3 ligand), while those from GKO mice migrated in re sponse to eotaxin/CCL11 (CCR3 ligand). These results suggest that IFN-gamma modulates the expression of chemokines and chemokine receptors as well as the kind of cells that infiltrate the lungs of Pb-infected mice.en
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Cell Biol, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Internal Med, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande Norte, Dept Microbiol & Parasitol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationNIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent583-590
dc.identifierhttp://dx.doi.org/10.1016/S0002-9440(10)63686-3
dc.identifier.citationAmerican Journal of Pathology. Bethesda: Amer Soc Investigative Pathology, Inc, v. 163, n. 2, p. 583-590, 2003.
dc.identifier.doi10.1016/S0002-9440(10)63686-3
dc.identifier.issn0002-9440
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27327
dc.identifier.wosWOS:000184366400020
dc.language.isoeng
dc.publisherAmer Soc Investigative Pathology, Inc
dc.relation.ispartofAmerican Journal of Pathology
dc.rightsAcesso aberto
dc.titleChemokine production and leukocyte recruitment to the lungs of Paracoccidioides brasiliensis-infected mice is modulated by interferon-gammaen
dc.typeArtigo
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