Serum NGAL and Cystatin C Comparison With Urinary Albumin-to-Creatinine Ratio and Inflammatory Biomarkers as Early Predictors of Renal Dysfunction in Patients With Type 2 Diabetes

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dc.citation.issue2
dc.citation.volume2
dc.contributor.authorBacci, Marcelo R.
dc.contributor.authorChehter, Ethel Z.
dc.contributor.authorAzzalis, Ligia A. [UNIFESP]
dc.contributor.authorde Aguiar Alves, Beatriz Costa
dc.contributor.authorFonseca, Fernando L. A.
dc.coverageNew Delhi
dc.date.accessioned2020-07-17T14:02:41Z
dc.date.available2020-07-17T14:02:41Z
dc.date.issued2017
dc.description.abstractIntroduction: Diabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved with biomarkers of diabetes. The aim of this study was to evaluate the accuracy of kidney dysfunction biomarkers in type 2 diabetes (T2D). Methods: Patients with T2D were grouped according to their glycated hemoglobin level. Patients' urine and blood samples were taken to measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, and the first morning void albumin-to-creatinine ratio. Patients in the end stage of renal disease or receiving dialysis were not included. Receiver operating characteristic curves were generated, and the areas under the curve were compared with the performance of the biomarkers used to evaluate kidney dysfunction in T2D. Results: Ninety patients with T2D were chosen. CysC was positively correlated with creatinine (P < 0.001), estimated glomerular filtration rate (P < 0.001), and urinary beta-trace protein (P = 0.01). The area under the curve was 0.635 for CysC, 0.621 for serum neutrophil gelatinase-associated lipocalin, and 0.660 for the albumin-to-creatinine ratio. A crude logistic regression model showed a positive association between serum CysC (P = 0.01) and serum neutrophil gelatinase-associated lipocalin (P < 0.001). A linear regression model showed a positive association between serum CysC, creatinine, and estimated glomerular filtration rate (P < 0.001) but did not show a positive association with glycated hemoglobin (P = 0.892). Discussion: Neutrophil gelatinase-associated lipocalin and serum CysC were positively associated with the presence of renal dysfunction and had better performance on receiver operating characteristic analysis than the other markers evaluated in patients with T2D without kidney dysfunction.en
dc.description.affiliationFac Med ABC, Dept Gen Practice, Santo Andre, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Earth Sci Dept, Sao Paulo, Fac Med ABC, Clin Anal Lab, Santo Andre, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Earth Sci Dept, Sao Paulo, Fac Med ABC, Clin Anal Lab, Santo Andre, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundaao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipNucleo de Assistencia a Pesquisa Clinica
dc.description.sponsorshipIDFAPESP: 2014/04596-8
dc.format.extent152-158
dc.identifierhttp://dx.doi.org/10.1016/j.ekir.2016.10.001
dc.identifier.citationKidney International Reports. New Delhi, v. 2, n. 2, p. 152-158, 2017.
dc.identifier.doi10.1016/j.ekir.2016.10.001
dc.identifier.issn2468-0249
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54948
dc.identifier.wosWOS:000405959300007
dc.language.isoeng
dc.publisherElsevier - Division Reed Elsevier India Pvt Ltd
dc.relation.ispartofKidney International Reports
dc.rightsAcesso aberto
dc.subjectalbuminuriaen
dc.subjectbiomarkersen
dc.subjectcystatin Cen
dc.subjectdiabetic kidney diseaseen
dc.subjectNGALen
dc.titleSerum NGAL and Cystatin C Comparison With Urinary Albumin-to-Creatinine Ratio and Inflammatory Biomarkers as Early Predictors of Renal Dysfunction in Patients With Type 2 Diabetesen
dc.typeArtigo
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