Low-intensity Treadmill Exercise-related Changes in the Rat Stellate Ganglion Neurons

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dc.contributor.authorOliveira Cavalcanti, Renato Albuquerque de
dc.contributor.authorPureza, Demilto Yamaguchi da
dc.contributor.authorMelo, Mariana Pereira de
dc.contributor.authorSouza, Romeu Rodrigues de
dc.contributor.authorBergamaschi, Cassia T. [UNIFESP]
dc.contributor.authorAmaral, Sandra Lia do
dc.contributor.authorTang, Helen
dc.contributor.authorLoesch, Andrzej
dc.contributor.authorCoppi Maciel Ribeiro, Antonio Augusto
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Sao Judas Tadeu
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo State Univ
dc.contributor.institutionUCL
dc.date.accessioned2016-01-24T13:52:29Z
dc.date.available2016-01-24T13:52:29Z
dc.date.issued2009-05-01
dc.description.abstractStellate ganglion (SG) represents the main sympathetic input to the heart. This study aimed at investigating physical exercise-related changes in the quantitative aspects of SG neurons in treadmill-exercised Wistar rats. By applying state-of-the-art design-based stereology, the SG volume, total number of SG neurons, mean perikaryal volume of SG neurons, and the total volume of neurons in the whole SG have been examined. Arterial pressure and heart rate were also measured at the end of the exercise period. the present study showed that a low-intensity exercise training program caused a 12% decrease in the heart rate of trained rats. in contrast, there were no effects on systolic pressure, diastolic pressure, or mean arterial pressure. As to quantitative changes related to physical exercise, the main findings were a 21% increase in the fractional volume occupied by neurons in the SG, and an 83% increase in the mean perikaryal volume of SG neurons in treadmill-trained rats, which shows a remarkable neuron hypertrophy. It seems reasonable to infer that neuron hypertrophy may have been the result of a functional overload imposed on the SG neurons by initial posttraining sympathetic activation. From the novel stereological data we provide, further investigations are needed to shed light on the mechanistic aspect of neuron hypertrophy: what role does neuron hypertrophy play? Could neuron hypertrophy be assigned to the functional overload induced by physical exercise? (C) 2008 Wiley-Liss, Inc.en
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecnia, Dept Cirurgia, Coll Vet Med,LSSCA, BR-05508270 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Math & Stat, Dept Stat, BR-05508270 São Paulo, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Phys Educ Postgrad Course, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, Santos, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Fac Sci, Dept Phys Educ, Bauru, Brazil
dc.description.affiliationUCL, Sch Med, Res Dept Inflammat, London W1N 8AA, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 05/02411-1
dc.format.extent1334-1342
dc.identifierhttp://dx.doi.org/10.1002/jnr.21961
dc.identifier.citationJournal of Neuroscience Research. Hoboken: Wiley-liss, v. 87, n. 6, p. 1334-1342, 2009.
dc.identifier.doi10.1002/jnr.21961
dc.identifier.issn0360-4012
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31487
dc.identifier.wosWOS:000264907400006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Neuroscience Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectstereologyen
dc.subjectextrinsic cardiac innervationen
dc.subjectphysical exerciseen
dc.subjectstellate ganglionen
dc.subjectratsen
dc.titleLow-intensity Treadmill Exercise-related Changes in the Rat Stellate Ganglion Neuronsen
dc.typeinfo:eu-repo/semantics/article
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