Precocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult mice

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dc.citation.issue3
dc.citation.volume12
dc.contributor.authorRibeiro, Rosemara Silva [UNIFESP]
dc.contributor.authorPassos, Clévia dos Santos [UNIFESP]
dc.contributor.authorNovaes, Antonio da Silva [UNIFESP]
dc.contributor.authorMaquigussa, Edgar [UNIFESP]
dc.contributor.authorGloria, Maria Aparecida da [UNIFESP]
dc.contributor.authorVisona, Iria [UNIFESP]
dc.contributor.authorYkuta, Olinda [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-17T14:02:37Z
dc.date.available2020-07-17T14:02:37Z
dc.date.issued2017
dc.description.abstractObesity and its consequences can damage the kidney over time. However, less is known about the impact of developing overweight/obesity during childhood on the kidney in adulthood and the renal impact of a superimposed acute kidney injury (AKI). This study evaluated the effect of obesity induced by a high-fat diet initiated soon after weaning on the adult life of mice and their response to superimposed nephrotoxic effects of cisplatin. C57BL/6 post weaning mice (3 weeks old) were divided into a control group (CT, n = 12) and a high-fat diet group (HF, n = 12). After 9 weeks, animals were further divided into the following groups: CT, CT treated with a single dose of cisplatin (CTCis, 20 mg/kg, i.p.), HF and HF treated with cisplatin (HFCis). The HF group exhibited higher body weight gain compatible with a moderate obesity. Obese mice presented increased visceral adiposity, hyperkalemia, sodium retention, glomerular hyperfiltration and proteinuria, without any significant changes in blood pressure and glycemia. AKI induced by cisplatin was exacerbated in obese animals with a 92% reduction in the GFR versus a 31% decrease in the CTCis groupen
dc.description.abstractthis sharp decline resulted in severely elevated serum creatinine and urea levels. Acute tubular necrosis induced by cisplatin was worsened in obese mice. The HFCis group exhibited robust systemic and intrarenal inflammation that was significantly higher than that in the CTCis groupen
dc.description.abstractthe HFCis group also showed a higher degree of renal oxidative stress. In conclusion, the moderate degree of obesity induced shortly after weaning resulted in mild early renal alterations, however, obese young animals were prone to develop a much more severe AKI induced by cisplatin.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nutr Physiol, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nutr Physiol, Dept Physiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação Oswaldo Ramos
dc.description.sponsorshipIDCNPq: 470662/2013-1
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.1371/journal.pone.0174721
dc.identifier.citationPlos One. San Francisco, v. 12, n. 3, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0174721
dc.identifier.fileWOS000399174800078.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54906
dc.identifier.wosWOS:000399174800078
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePrecocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult miceen
dc.typeinfo:eu-repo/semantics/article
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