Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior

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dc.contributor.authorTakada, Silvia Honda
dc.contributor.authorMotta-Teixeira, Livia Clemente
dc.contributor.authorMachado-Nils, Aline Vilar
dc.contributor.authorLee, Vitor Yonamine
dc.contributor.authorSampaio, Carlos Alberto
dc.contributor.authorPolli, Roberson Saraiva [UNIFESP]
dc.contributor.authorMalheiros, Jackeline Moraes [UNIFESP]
dc.contributor.authorTakase, Luiz Fernando
dc.contributor.authorKihara, Alexandre Hiroaki
dc.contributor.authorCovolan, Luciene [UNIFESP]
dc.contributor.authorXavier, Gilberto Fernando
dc.contributor.authorNogueira, Maria Ines
dc.date.accessioned2018-07-26T17:30:32Z
dc.date.available2018-07-26T17:30:32Z
dc.date.issued2016
dc.description.abstractNeonates that suffer oxygen deprivation during birth can have long lasting cognitive deficits, such as memory and learning impairments. Hippocampus, one of the main structures that participate in memory and learning processes, is a plastic and dynamic structure that conserves during life span the property of generating new cells which can become neurons, the so-called neurogenesis. The present study investigated whether a model of rat neonatal anoxia, that causes only respiratory distress, is able to alter the hippocampal volume, the neurogenesis rate and has functional implications in adult life. MRI analysis revealed significant hippocampal volume decrease in adult rats who had experienced neonatal anoxia compared to control animals for rostra!, caudal and total hippocampus. In addition, these animals also had 55.7% decrease of double-labelled cells to BrdU and NeuN, reflecting a decrease in neurogenesis rate. Finally, behavioral analysis indicated that neonatal anoxia resulted in disruption of spatial working memory, similar to human condition, accompanied by an anxiogenic effect. The observed behavioral alterations caused by oxygen deprivation at birth might represent an outcome of the decreased hippocampal neurogenesis and volume, evidenced by immunohistochemistry and MRI analysis. Therefore, based on current findings we propose this model as suitable to explore new therapeutic approaches. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.affiliationDepartamento de Anatomia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
dc.description.affiliationNúcleo de Cognição e Sistemas Complexos, Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo André, Brazil
dc.description.affiliationDepartamento de Fisiologia Geral, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil
dc.description.affiliationDepartamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationDepartamento de Morfologia e Patologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil
dc.description.affiliationUnifespDepartamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/01488-9
dc.description.sponsorshipIDFAPESP: 2009/51557-0
dc.format.extent331-338
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2015.08.039
dc.identifier.citationBehavioural Brain Research. Amsterdam, v. 296, p. 331-338, 2016.
dc.identifier.doi10.1016/j.bbr.2015.08.039
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/46099
dc.identifier.wosWOS:000366079100042
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNeonatal anoxiaen
dc.subjectMRIen
dc.subjectHippocampal neurogenesisen
dc.subjectWorking memoryen
dc.subjectAnxietyHypoxic-Ischemic Encephalopathyen
dc.subjectPreterm Fetal Sheepen
dc.subjectBrain-Injuryen
dc.subjectPerinatal Asphyxiaen
dc.subjectTransient Hypoxiaen
dc.subjectCerebral-Palsyen
dc.subjectSpatial Memoryen
dc.subjectModelen
dc.subjectCellsen
dc.subjectProliferationen
dc.titleImpact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavioren
dc.typeinfo:eu-repo/semantics/article
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