Melatonin administration after pilocarpine-induced status epilepticus: A new way to prevent or attenuate postlesion epilepsy?

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dc.contributor.authorLima, Eliangela
dc.contributor.authorCabral, Francisco R.
dc.contributor.authorCavalheiro, Esper A.
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorAmado, Debora [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.date.accessioned2016-01-24T14:06:22Z
dc.date.available2016-01-24T14:06:22Z
dc.date.issued2011-04-01
dc.description.abstractObjective: the goal of this study was to verify the effects of treatment with melatonin and N-acetylserotonin on the pilocarpine-induced epilepsy model.Methods: the animals were divided into four groups: (1) animals treated with saline (Saline); (2) animals that received pilocarpine and exhibited SE (SE); (3) animals that exhibited SE and were treated with N-acetylserotonin (30 minutes and 1, 2, 4, 6, 12, 24, 36, and 48 hours) alter SE onset (SE + NAS); (4) animals that exhibited SE and were treated with melatonin at the same time the SE + NAS group (SE + MEL). Behavioral (latency to first seizure, frequency of seizures, and mortality) and histological (Nissl and neo-Timm) parameters were analyzed.Results: the animals treated with melatonin (SE + MEL) had a decreased number of spontaneous seizures during the chronic period (P<0.05), a reduction in mossy fiber sprouting, and less cell damage than the SE group. Animals treated with N-acetylserotonin did not exhibit any kind of significant change.Conclusion: Melatonin exerts an important neuroprotective effect by attenuating SE-induced postlesion and promoting a decrease in the number of seizures in epileptic rats. This suggests, for the first time, that melatonin could be used co-therapeutically in treatment of patients exhibiting SE to minimize associated injuries in these situations. (C) 2011 Published by Elsevier Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Neurol Expt, Escola Paulista Med, UNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Bioquim, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Cerebro, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Neurol Expt, Escola Paulista Med, UNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Bioquim, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCInAPCe
dc.format.extent607-612
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2011.01.018
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 20, n. 4, p. 607-612, 2011.
dc.identifier.doi10.1016/j.yebeh.2011.01.018
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33605
dc.identifier.wosWOS:000290056200004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEpilepsyen
dc.subjectMelatoninen
dc.subjectN-acetylserotoninen
dc.subjectStatus epilepticusen
dc.subjectNeuroprotectionen
dc.subjectExperimental modelen
dc.subjectPilocarpineen
dc.titleMelatonin administration after pilocarpine-induced status epilepticus: A new way to prevent or attenuate postlesion epilepsy?en
dc.typeinfo:eu-repo/semantics/article
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