Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

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dc.citation.issue11
dc.citation.volume11
dc.contributor.authorBittencourt, Celia Regina de Olivera [UNIFESP]
dc.contributor.authorIzar, Maria Cristina de Oliveira [UNIFESP]
dc.contributor.authorSchwerz, Valdir Lauro [UNIFESP]
dc.contributor.authorPóvoa, Rui Manuel dos Santos [UNIFESP]
dc.contributor.authorFonseca, Henrique Andrade Rodrigues da [UNIFESP]
dc.contributor.authorFonseca, Marília Izar Helfenstein [UNIFESP]
dc.contributor.authorBianco, Henrique Tria [UNIFESP]
dc.contributor.authorFranca, Carolina Nunes [UNIFESP]
dc.contributor.authorFerreira, Carlos Eduardo dos Santos [UNIFESP]
dc.contributor.authorFonseca, Francisco Antonio Helfenstein [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-07-31T12:47:17Z
dc.date.available2020-07-31T12:47:17Z
dc.date.issued2016
dc.description.abstractTo evaluate the effects of long-term exposure to high-intensity training among professional runners on cardiac hypertrophy and subclinical atherosclerosis. Prospective study included runners of both sexes (n = 52) and age and gender matched controls (n = 57), without classical cardiovascular risk factors. Ventricular hypertrophy was quantified by echocardiography by linear method and carotid intima-media thickness (cIMT) by 2-D images obtained by ultrasonography. Endothelial function was evaluated by flowmediated dilation (FMD). Steroid hormones were quantified by HPLC followed by LC-MS/MS. Higher left ventricular (LV) mass index was found in male athletes (p< 0.0001 vs. other groups). When adjusted for gender, the degree of left ventricular mass index classified as mildly, moderately or severely abnormal was obtained in 26%, 35%, and 30%, respectively, of female athletes, and in 39%, 14%, and 21%, respectively, of male athletes. Higher ratio of the early (E) to late (A) ventricular filling velocities was found in athletes of both genders. Male athletes presented lower cIMT in the right (p = 0.012 vs. male controls) and left (p< 0.0001 vs. male controls) common carotid arteries, without differences in cIMT between female athletes and controls. FMD results were similar among groups. Higher serum testosterone levels were found in male athletes (p< 0.0001 vs. other groups) and they were correlated with LV mass (r = 0.50, p< 0.0001). The chronic exposure of high-intensity training among professional runners of both genders was associated with increased ventricular mass and adaptive remodeling. Less subclinical atherosclerosis was found in male athletes. Differences in steroid hormones may account in part for these findings.en
dc.description.affiliationUniv Fed Sao Paulo, Div Cardiol, Sao Paulo, Brazil
dc.description.affiliationUniv Santo Amaro, Sao Paulo, Brazil
dc.description.affiliationAlbert Einstein Israeli Hosp, Sao Paulo, Brazil
dc.description.affiliationUnifespCardiology Division, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/50242-2
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0166009
dc.identifier.citationPlos One. San Francisco, v. 11, n. 11, p. -, 2016.
dc.identifier.doi10.1371/journal.pone.0166009
dc.identifier.fileWOS000387779200019.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56718
dc.identifier.wosWOS:000387779200019
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosisen
dc.typeinfo:eu-repo/semantics/article
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