Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohort

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dc.citation.issue1
dc.citation.volume26
dc.contributor.authorPons-Estel, G. J.
dc.contributor.authorAspey, L. D.
dc.contributor.authorBao, G.
dc.contributor.authorPons-Estel, B. A.
dc.contributor.authorWojdyla, D.
dc.contributor.authorSaurit, V.
dc.contributor.authorAlvarellos, A.
dc.contributor.authorCaeiro, F.
dc.contributor.authorHaye Salinas, M. J.
dc.contributor.authorSato, Emilia Inoue [UNIFESP]
dc.contributor.authorSoriano, E. R.
dc.contributor.authorCostallat, L. T. L.
dc.contributor.authorNeira, O.
dc.contributor.authorIglesias-Gamarra, A.
dc.contributor.authorReyes-Llerena, G.
dc.contributor.authorCardiel, M. H.
dc.contributor.authorAcevedo-Vasquez, E. M.
dc.contributor.authorChacon-Diaz, R.
dc.contributor.authorDrenkard, C.
dc.coverageLondon
dc.date.accessioned2020-07-31T12:46:59Z
dc.date.available2020-07-31T12:46:59Z
dc.date.issued2017
dc.description.abstractObjectives The objective of this study was to examine whether early discoid lupus erythematosus (DLE) would be a protective factor for further lupus nephritis in patients with systemic lupus erythematosus (SLE). Methods We studied SLE patients from GLADEL, an inception longitudinal cohort from nine Latin American countries. The main predictor was DLE onset, which was defined as physician-documented DLE at SLE diagnosis. The outcome was time from the diagnosis of SLE to new lupus nephritis. Univariate and multivariate survival analyses were conducted to examine the association of DLE onset with time to lupus nephritis. Results Among 845 GLADEL patients, 204 (24.1%) developed lupus nephritis after SLE diagnosis. Of them, 10 (4.9%) had DLE onset, compared to 83 (12.9%) in the group of 641 patients that remained free of lupus nephritis (hazard ratio 0.39en
dc.description.abstractP=0.0033). The cumulative proportion of lupus nephritis at 1 and 5 years since SLE diagnosis was 6% and 14%, respectively, in the DLE onset group, compared to 14% and 29% in those without DLE (P=0.0023). DLE onset was independently associated with a lower risk of lupus nephritis, after controlling for sociodemographic factors and disease severity at diagnosis (hazard ratio 0.38en
dc.description.abstract95% confidence interval 0.20-0.71). Conclusions Our data indicate that DLE onset reduces the risk of further lupus nephritis in patients with SLE, independently of other factors such as age, ethnicity, disease activity, and organ damage. These findings have relevant prognosis implications for SLE patients and their clinicians. Further studies are warranted to unravel the biological and environmental pathways associated with the protective role of DLE against renal disease in patients with SLE.en
dc.description.affiliationInst Clin Med & Dermatol, Dept Autoimmune Dis, Barcelona, Spain
dc.description.affiliationEmory Sch Med, Dept Dermatol, Atlanta, GA USA
dc.description.affiliationEmory Sch Med, Div Rheumatol, Atlanta, GA USA
dc.description.affiliationHosp Prov Rosario, Serv Reumatol, Rosario, Santa Fe, Argentina
dc.description.affiliationUniv Nacl Rosario, Rosario, Santa Fe, Argentina
dc.description.affiliationHosp Privado, Serv Reumatol, Cordoba, Argentina
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Med, Sao Paulo, Brazil
dc.description.affiliationHosp Italiano Buenos Aires, Secc Reumatol, Buenos Aires, DF, Argentina
dc.description.affiliationFdn Dr Pedro M Catoggio Progreso Reumatol, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Estadual Campinas, Div Reumatol, Campinas, SP, Brazil
dc.description.affiliationUniv Chile, Hosp Salvador, Fac Med, Secc Reumatol, Santiago, Chile
dc.description.affiliationUniv Nacl Colombia, Fac Med, Bogota, Colombia
dc.description.affiliationCtr Invest Med Quirurg CIMEQ, Serv Nacl Reumatol, Havana, Cuba
dc.description.affiliationCtr Invest Clin Morelia, Morelia, Michoacan, Mexico
dc.description.affiliationUniv Nacl Mayor San Marcos, Hosp Nacl Guillermo Almenara Irigoyen, Sch Med, Serv Reumatol, Lima, Peru
dc.description.affiliationUniv Hosp, Serv Reumatol, Caracas, Venezuela
dc.description.affiliationUnifespDepartamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFederico Wilhelm Agricola Foundation Research
dc.description.sponsorshipSupporting Training Efforts in Lupus for Latin-American Rheumatologists (STELLAR) Program - Rheuminations, Inc.
dc.description.sponsorshipInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS)-Beca de Formacio i Contractacio de Personal Investigador
dc.description.sponsorshipNational Institutes of Health (NIH)
dc.description.sponsorshipCenters for Disease Control and Prevention (CDC)
dc.description.sponsorshipIDNIH: R01AR065493
dc.description.sponsorshipIDCDC: U01-DP14-004
dc.format.extent73-83
dc.identifierhttp://dx.doi.org/10.1177/0961203316651740
dc.identifier.citationLupus. London, v. 26, n. 1, p. 73-83, 2017.
dc.identifier.doi10.1177/0961203316651740
dc.identifier.issn0961-2033
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56507
dc.identifier.wosWOS:000390847600010
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofLupus
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSystemic lupus erythematosusen
dc.subjectlupus nephritisen
dc.subjectdiscoid lupus erythematosusen
dc.subjectsurvival analysisen
dc.subjectGLADEL cohorten
dc.titleEarly discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohorten
dc.typeinfo:eu-repo/semantics/article
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