Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy

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dc.contributor.authorBravo, Daniela M. [UNIFESP]
dc.contributor.authorGimenes, Ana Cristina [UNIFESP]
dc.contributor.authorNascimento, Rubia B. [UNIFESP]
dc.contributor.authorFerreira, Eloara V. M. [UNIFESP]
dc.contributor.authorSiqueira, Ana Cristina B. [UNIFESP]
dc.contributor.authorMeda, Ethiane D. S. [UNIFESP]
dc.contributor.authorNeder, J. Alberto [UNIFESP]
dc.contributor.authorNery, Luiz Eduardo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:10Z
dc.date.available2016-01-24T14:27:10Z
dc.date.issued2012-05-01
dc.description.abstractThis study addressed whether O-2 delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to O-2 utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary O-2 uptake (V) over dotO(2p)); (2) an index of fractional O-2 extraction by near-infrared spectroscopy (Delta[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (Q'(T)) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age-and gender-matched controls. Kinetics of (V) over dotO(2p) were significantly slower in patients than controls (tau = 53.8 +/- 16.5 vs. 38.8 +/- 7.6 s, respectively; p < 0.05). Q'(T)0, however, declined at similar rates (s = 64.7 +/- 18.8 vs. 73.0 +/- 21.6 s; p > 0.05) being typically slower than (V) over dotO(2p) in both groups. Importantly, Delta[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, tau(V) over dotO(2p) in patients and controls, respectively. in fact, there were no between-group differences in tau(V) over dotO(2p)/MRTD[deoxy-Hb + Mb] (1.1 +/- 0.4 vs. 1.0 +/- 0.2, p > 0.05) thereby indicating similar rates of microvascular O-2 delivery. These data indicate that the slower rate of recovery of muscle metabolism after highintensity exercise is not related to impaired microvascular O-2 delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population.en
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Pulm Funct & Clin Exercise Physiol Unit, Div Resp Med,Dept Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Pulm Funct & Clin Exercise Physiol Unit, Div Resp Med,Dept Med, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1763-1771
dc.identifierhttp://dx.doi.org/10.1007/s00421-011-2136-4
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 112, n. 5, p. 1763-1771, 2012.
dc.identifier.doi10.1007/s00421-011-2136-4
dc.identifier.issn1439-6319
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34838
dc.identifier.wosWOS:000302745700020
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectMitochondrial myopathyen
dc.subjectReoxygenationen
dc.subjectOxygen uptakeen
dc.subjectKineticsen
dc.subjectExercise recoveryen
dc.titleSkeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathyen
dc.typeinfo:eu-repo/semantics/article
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