Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence

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dc.citation.issue1
dc.citation.volume75
dc.contributor.authorRodrigues, Daniela Laranja Gomes [UNIFESP]
dc.contributor.authorAdegoke, Samuel Ademola [UNIFESP]
dc.contributor.authorCampos, Rejane de Souza Macedo [UNIFESP]
dc.contributor.authorBraga, Josefina Aparecida Pellegrini [UNIFESP]
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.contributor.authorSilva, Gisele Sampaio [UNIFESP]
dc.coverageSao Paulo Sp
dc.date.accessioned2020-07-31T12:46:55Z
dc.date.available2020-07-31T12:46:55Z
dc.date.issued2017
dc.description.abstractTranscranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationObafemi Awolowo Univ, Dept Pediat & Child Hlth, Ife, Nigeria
dc.description.affiliationUniv Fed Sao Paulo, Dept Oncol Clin & Expt, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Programa Integrado Neurol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Oncologia Clínica e Experimental, São Paulo SP, Brasil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Pediatria, São Paulo SP, Brasil
dc.description.sourceWeb of Science
dc.format.extent15-19
dc.identifierhttp://dx.doi.org/10.1590/0004-282X20160175
dc.identifier.citationArquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.
dc.identifier.doi10.1590/0004-282X20160175
dc.identifier.fileS0004-282X2017000100015.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X2017000100015
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56458
dc.identifier.wosWOS:000393268400004
dc.language.isoeng
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsickle cell diseaseen
dc.subjectultrasonographyen
dc.subjectdoppleren
dc.subjecttranscranialen
dc.subjectstrokeen
dc.titlePatients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidenceen
dc.typeinfo:eu-repo/semantics/article
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