CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze
dc.contributor.author | Vicentini, Jéssica Elias [UNIFESP] | |
dc.contributor.author | Céspedes, Isabel Cristina [UNIFESP] | |
dc.contributor.author | Nascimento, Juliana Olivetti Guzman [UNIFESP] | |
dc.contributor.author | Bittencourt, Jackson C. | |
dc.contributor.author | Viana, Milena de Barros [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2016-01-24T14:35:23Z | |
dc.date.available | 2016-01-24T14:35:23Z | |
dc.date.issued | 2014-03-01 | |
dc.description.abstract | Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. in the present study, we investigated the role played by the CRF system within the medial amygdala (MeA) in the modulation of anxiety and fear-related responses. Male Wistar rats were bilaterally administered into the MeA with CRF (125 and 250 ng/0.2 mu l, experiment 1) or with the CRFR1 antagonist antalarmin (25 ng/0.2 mu l, experiment 2) and 10 min later tested in the elevated T-maze (ETM) for inhibitory avoidance and escape measurements. in clinical terms, these responses have been respectively related to generalized anxiety and panic disorder. To further verify if the anxiogenic effects of CRF were mediated by CRFR1 activation, we also investigated the effects of the combined treatment with CRF (250 ng/0.2 mu l) and antalarmin (25 ng/0.2 mu l) (experiment 3). All animals were tested in an open field, immediately after the ETM, for locomotor activity assessment. Results showed that CRF, in the two doses administered, facilitated ETM avoidance, an anxiogenic response. Antalarmin significantly decreased avoidance latencies, an anxiolytic effect, and was able to counteract the anxiogenic effects of CRF. None of the compounds administered altered escape responses or locomotor activity measurements. These results suggest that CRF in the MeA exerts anxiogenic effects by activating type 1 receptors, which might be of relevance to the physiopathology of generalized anxiety disorder. (C) 2014 Elsevier Inc. All rights reserved. | en |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Psiquiatria & Psicol Med, BR-04038020 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Anat, Inst Ciencias Biomed, BR-05508000 São Paulo, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Biociencias, BR-11060001 Santos, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Psiquiatria & Psicol Med, BR-04038020 São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 195-202 | |
dc.identifier | https://dx.doi.org/10.1016/j.yhbeh.2014.01.004 | |
dc.identifier.citation | Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 65, n. 3, p. 195-202, 2014. | |
dc.identifier.doi | 10.1016/j.yhbeh.2014.01.004 | |
dc.identifier.issn | 0018-506X | |
dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/37504 | |
dc.identifier.wos | WOS:000333228900001 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Hormones and Behavior | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.subject | Corticotropin-releasing factor CRF | en |
dc.subject | Medial amygdala | en |
dc.subject | Elevated T-maze | en |
dc.subject | Anxiety | en |
dc.subject | Fear | en |
dc.subject | Panic | en |
dc.title | CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze | en |
dc.type | info:eu-repo/semantics/article |