Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats
dc.contributor.author | Gumieiro, Emne Hammoud [UNIFESP] | |
dc.contributor.author | Abrahão, Márcio [UNIFESP] | |
dc.contributor.author | Jahn, Ricardo Schmitutz [UNIFESP] | |
dc.contributor.author | Segretto, Helena [UNIFESP] | |
dc.contributor.author | Alves, Maria Teresa de Seixas [UNIFESP] | |
dc.contributor.author | Nannmark, Ulf | |
dc.contributor.author | Granström, Gösta | |
dc.contributor.author | Dib, Luciano Lauria [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Göteborg University Department of Anatomy and Cell Biology | |
dc.contributor.institution | The Sahlgrenska Academy of Göteborg University Institute for Clinical Sciences Department of Otolaryngology, Head and Neck Surgery | |
dc.contributor.institution | Paulista University Faculty of Dentistry Department of Stomatology | |
dc.date.accessioned | 2015-06-14T13:41:42Z | |
dc.date.available | 2015-06-14T13:41:42Z | |
dc.date.issued | 2010-06-01 | |
dc.description.abstract | PURPOSE: To evaluate the influence of PRP addition on bone repair of circular defects created in irradiated tibiae of rats by histometric analysis. METHODS: Sixty male Wistar rats had the right tibiae irradiated with 30 Gy. After 30 days monocortical defects were created and platelet-rich plasma was applied in 30 rats. In the control group defects were created but not filled. The animals were desanguinated after 4, 7, 14, 21, 56 and 84 days and the tibiae removed for histological processing. RESULTS: There was a tendency in the PRP group to increased bone neoformation from 14-days to 84-days; in the control group increased bone neoformation was not seen after 21 days or later. CONCLUSION: The addition of platelet-rich plasma had a beneficial effect in the initial cellular regeneration period and enhanced bone formation in later periods when compared to control. | en |
dc.description.abstract | OBJETIVO: Avaliar histometricamente a influência do PRP na reparação óssea de defeitos circulares criados em tíbia irradiada de ratos Wistar. MÉTODOS: Sessenta ratos machos tiveram a tíbia direita irradiada com 30Gy. Após 30 dias, defeitos ósseos monocorticais foram criados e PRP foi adicionado em 30 ratos. No grupo controle os defeitos foram criados, mas não preenchidos. Os animais foram sacrificados em 4, 7, 14, 21, 56 e 84 dias e a tíbia removida para processamento histológico. RESULTADOS: Houve uma tendência do grupo PRP mostrar uma neoformação óssea significativamente maior nos períodos de 14 a 84 dias; no grupo controle o aumento da reparação óssea não se manteve após 21 dias. CONCLUSÃO: A adição de PRP mostrou-se benéfica no período inicial de reparação celular e em períodos seqüentes foi estímulo à quantidade neoformação óssea, quando comparado ao controle. | pt |
dc.description.affiliation | Universidade Federal de São Paulo (UNIFESP) Department of Otorhinolaringology and Head and Neck Surgery | |
dc.description.affiliation | Universidade Federal de São Paulo (UNIFESP) Department of Oncology | |
dc.description.affiliation | Universidade Federal de São Paulo (UNIFESP) Department of Patology | |
dc.description.affiliation | Göteborg University Department of Anatomy and Cell Biology | |
dc.description.affiliation | The Sahlgrenska Academy of Göteborg University Institute for Clinical Sciences Department of Otolaryngology, Head and Neck Surgery | |
dc.description.affiliation | Paulista University Faculty of Dentistry Department of Stomatology | |
dc.description.affiliationUnifesp | UNIFESP, Department of Otorhinolaringology and Head and Neck Surgery | |
dc.description.affiliationUnifesp | UNIFESP, Department of Oncology | |
dc.description.affiliationUnifesp | UNIFESP, Department of Patology | |
dc.description.source | SciELO | |
dc.format.extent | 257-263 | |
dc.identifier | http://dx.doi.org/10.1590/S0102-86502010000300007 | |
dc.identifier.citation | Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 25, n. 3, p. 257-263, 2010. | |
dc.identifier.doi | 10.1590/S0102-86502010000300007 | |
dc.identifier.file | S0102-86502010000300007.pdf | |
dc.identifier.issn | 0102-8650 | |
dc.identifier.scielo | S0102-86502010000300007 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/5765 | |
dc.identifier.wos | WOS:000279280900007 | |
dc.language.iso | eng | |
dc.publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia | |
dc.relation.ispartof | Acta Cirurgica Brasileira | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Platelet-Rich Plasma | en |
dc.subject | Radiation Injuries, Experimental | en |
dc.subject | Bone Regeneration | en |
dc.subject | Plasma Rico em Plaquetas | pt |
dc.subject | Lesões Experimentais por Radiação | pt |
dc.subject | Regeneração Óssea | pt |
dc.title | Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats | en |
dc.title.alternative | Plasma rico em plaquetas na reparação óssea em tíbias irradiadas de ratos Wistar | pt |
dc.type | info:eu-repo/semantics/article |
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