Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study

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dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorSalum, Giovanni Abrahao
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorVieira, Gilson
dc.contributor.authorZugman, Andre [UNIFESP]
dc.contributor.authorPicon, Felipe Almeida
dc.contributor.authorPan, Pedro Mario [UNIFESP]
dc.contributor.authorHoexter, Marcelo Queiroz [UNIFESP]
dc.contributor.authorAnes, Mauricio
dc.contributor.authorMoura, Luciana Monteiro [UNIFESP]
dc.contributor.authorGomes Del'Aquilla, Marco Antonio [UNIFESP]
dc.contributor.authorCrossley, Nicolas
dc.contributor.authorAmaro Junior, Edson
dc.contributor.authorMcguire, Philip
dc.contributor.authorLacerda, Acioly L. T. [UNIFESP]
dc.contributor.authorRohde, Luis Augusto
dc.contributor.authorMiguel, Euripedes Constantino
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionKings Coll London
dc.contributor.institutionCNPq
dc.date.accessioned2016-01-24T14:39:50Z
dc.date.available2016-01-24T14:39:50Z
dc.date.issued2015-01-01
dc.description.abstractInvestigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. the aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. the fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. for each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions.Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. in conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci LiNC, UNIFESP, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Bioinformat Program, Inst Math & Stat, BR-05508 São Paulo, Brazil
dc.description.affiliationKings Coll London, Inst Psychiat, London WC2R 2LS, England
dc.description.affiliationUniv São Paulo, Sch Med, Dept Radiol, BR-05508 São Paulo, Brazil
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci LiNC, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipIDFAPESP: 2013/10498-6
dc.description.sponsorshipIDFAPESP: 2013/00506-1
dc.description.sponsorshipIDCNPq: 573974/2008-0
dc.description.sponsorshipIDFAPESP: 2008/57896-8
dc.format.extent44-51
dc.identifierhttp://dx.doi.org/10.1016/j.neuroimage.2014.09.063
dc.identifier.citationNeuroimage. San Diego: Academic Press Inc Elsevier Science, v. 104, p. 44-51, 2015.
dc.identifier.doi10.1016/j.neuroimage.2014.09.063
dc.identifier.issn1053-8119
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38591
dc.identifier.wosWOS:000345393800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroimage
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectNeurodevelopmenten
dc.subjectNeuroimagingen
dc.subjectNetworksen
dc.subjectChildrenen
dc.subjectGraphen
dc.titleDecreased centrality of subcortical regions during the transition to adolescence: A functional connectivity studyen
dc.typeinfo:eu-repo/semantics/article
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