Measurement of Mouse Heart Rate Variability using Echocardiographic System

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dc.citation.issue2
dc.citation.volumev. 28
dc.contributor.authorStoyell-Conti, Filipe Fernandes
dc.contributor.authorSantos, Fernando
dc.contributor.authorMachi, Jacqueline Freire
dc.contributor.authorHernandez, Diana Rosa
dc.contributor.authorBarboza, Catarina Andrade
dc.contributor.authorIrigoyen, Maria-Claudia [UNIFESP]
dc.contributor.authorDe Angelis, Katia [UNIFESP]
dc.contributor.authorMorris, Mariana
dc.coverageMumbai
dc.date.accessioned2020-07-20T16:31:02Z
dc.date.available2020-07-20T16:31:02Z
dc.date.issued2018
dc.description.abstractAim: We employed an echocardiographic (ECHO) system as the backbone for the collection of electrocardiogram (ECG) and heart rate variability (HRV) data. The system was tested using an exercise model in which C57 male mice were exposed to sham or forced wheel running. Methods: Peak/peak (RR) interval was recorded over a 3 min period using the ECG platform of the ECHO system. Isoflurane-anesthetized male mice were divided into two groups (n = 8/group): sedentary (S) and forced wheel trained (T). HRV was analyzed in time and frequency domains (Fast Fourier Transform). Exercise training (T) was performed on a motorized wheel at low intensity 1 h/day, 5 days/week, 8 weeks duration. Cardiac morphometry and function were analyzed using ECHO while ECG was the basis to measure HRV. The sampling rate was 8000 Hz. Results show that the trained mice presented a reduction in heart rate as compared to the sedentary group. This was associated with lower cardiac sympathetic and higher parasympathetic modulation leading to an improved sympathetic/parasympathetic ratio (low-frequency band/high-frequency band). The trained group showed a reduction in isovolumetric relaxation time, reduced myocardial performance index, increased relative wall thickness, and left ventricle mass when compared to the sedentary group. Conclusion: Results document the utility of combining the ECHO and the ECG platform, allowing for the dual measurement of autonomic and cardiac function in mice.en
dc.description.affiliationNove Julho Univ, Lab Translat Physiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationNova Southeastern Univ, Inst Neuroimmune Med, 3440 S Univ Dr, Ft Lauderdale, FL 33328 USA
dc.description.affiliationMiami VA Healthcare Syst, Miami, FL USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipU.S. Department of Defense
dc.description.sponsorshipCNPq-BPQ
dc.description.sponsorshipIDCAPES: 99999.008874/2014-00
dc.description.sponsorshipIDU.S. Department of Defense: W81XWH-13-2-0085
dc.format.extent90-94
dc.identifierhttp://dx.doi.org/10.4103/jcecho.jcecho_51_17
dc.identifier.citationJournal Of Cardiovascular Echography. Mumbai, v. 28, n. 2, p. 90-94, 2018.
dc.identifier.doi10.4103/jcecho.jcecho_51_17
dc.identifier.fileWOS000433243100003.pdf
dc.identifier.issn2211-4122
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55652
dc.identifier.wosWOS:000433243100003
dc.language.isoeng
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofJournal Of Cardiovascular Echography
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEchocardiographyen
dc.subjectelectrocardiogramen
dc.subjectexercises trainingen
dc.subjectheart rate variabilityen
dc.subjectmiceen
dc.subjectnoninvasive methoden
dc.titleMeasurement of Mouse Heart Rate Variability using Echocardiographic Systemen
dc.typeinfo:eu-repo/semantics/article
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