Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease

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dc.contributor.authorKohanim, Sahar
dc.contributor.authorPalioura, Sotiria
dc.contributor.authorSaeed, Hajirah N.
dc.contributor.authorAkpek, Esen K.
dc.contributor.authorAmescua, Guillermo
dc.contributor.authorBasu, Sayan
dc.contributor.authorBlomquist, Preston H.
dc.contributor.authorBouchard, Charles S.
dc.contributor.authorDart, John K.
dc.contributor.authorGai, Xiaowu
dc.contributor.authorGomes, Jose A. P. [UNIFESP]
dc.contributor.authorGregory, Darren G.
dc.contributor.authorIyer, Geetha
dc.contributor.authorJacobs, Deborah S.
dc.contributor.authorJohnson, Anthony J.
dc.contributor.authorKinoshita, Shigeru
dc.contributor.authorMantagos, Iason S.
dc.contributor.authorMehta, Jodhbir S.
dc.contributor.authorPerez, Victor L.
dc.contributor.authorPflugfelder, Stephen C.
dc.contributor.authorSangwan, Virender S.
dc.contributor.authorSippel, Kimberly C.
dc.contributor.authorSotozono, Chie
dc.contributor.authorSrinivasan, Bhaskar
dc.contributor.authorTan, Donald T. H.
dc.contributor.authorTandon, Radhika
dc.contributor.authorTseng, Scheffer C. G.
dc.contributor.authorUeta, Mayumi
dc.contributor.authorChodosh, James
dc.date.accessioned2019-01-21T10:30:18Z
dc.date.available2019-01-21T10:30:18Z
dc.date.issued2016
dc.description.abstractThe intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. We have divided this review into two parts. Part I summarizes the epidemiology and immunopathogenesis of SJS/TEN and discusses systemic therapy and its possible benefits. We hope this review will help the ophthalmologist better understand the mechanisms of disease in SJS/TEN and enhance their care of patients with this complex and often debilitating disease. Part II (April 2016 issue) will focus on ophthalmic manifestations.en
dc.description.affiliationVanderbilt Univ, Sch Med, Vanderbilt Eye Inst, Nashville, TN 37212 USA
dc.description.affiliationUniv Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA
dc.description.affiliationHarvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA
dc.description.affiliationJohns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
dc.description.affiliationLV Prasad Eye Inst, Hyderabad, Andhra Pradesh, India
dc.description.affiliationUniv Texas SW Med Ctr Dallas, Dallas, TX 75390 USA
dc.description.affiliationLoyola Univ, Chicago, IL 60611 USA
dc.description.affiliationMoorfields Eye Hosp, NHS Fdn Trust, London, England
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Colorado, Sch Med, Rocky Mt Lions Eye Inst, Aurora, CO USA
dc.description.affiliationG Sitalakshmi Mem Clin Ocular Surface Disord, Sankara Nethralaya, India
dc.description.affiliationBoston Fdn Sight, Boston, MA USA
dc.description.affiliationUnited States Army Inst Surg Res, San Antonio, TX USA
dc.description.affiliationKyoto Prefectural Univ Med, Kyoto, Japan
dc.description.affiliationHarvard Univ, Sch Med, Boston Childrens Hosp, Boston, MA USA
dc.description.affiliationSingapore Eye Res Inst, Singapore Natl Eye Ctr, Singapore, Singapore
dc.description.affiliationBaylor Coll Med, Cullen Eye Inst, Houston, TX 77030 USA
dc.description.affiliationWeill Cornell Med Coll, New York, NY USA
dc.description.affiliationAll India Inst Med Sci, Rajendra Prasad Ctr Ophthalm Sci, Delhi, India
dc.description.affiliationOcular Surface Res & Educ Fdn, Ocular Surface Ctr, Miami, FL USA
dc.description.affiliationUnifespFederal University of São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipResearch to Prevent Blindness, NY, NY
dc.format.extent2-19
dc.identifierhttp://dx.doi.org/10.1016/j.jtos.2015.10.002
dc.identifier.citationOcular Surface. Amsterdam, v. 14, n. 1, p. 2-19, 2016.
dc.identifier.doi10.1016/j.jtos.2015.10.002
dc.identifier.issn1542-0124
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49695
dc.identifier.wosWOS:000367241300002
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofOcular Surface
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectapoptosisen
dc.subjectdrug-induced diseaseen
dc.subjectimmune-mediated diseaseen
dc.subjectkeratinocyte death Stevens-Johnson Syndromeen
dc.subjecttoxic epidermal necrolysisAdverse Drug-Reactionsen
dc.subjectColony-Stimulating Factoren
dc.subjectIntravenous Immunoglobulin Therapyen
dc.subjectOcular Surface Complicationsen
dc.subjectDexamethasone Pulse Therapyen
dc.subjectSevere Mucosal Involvementen
dc.subjectErythema Multiforme Majoren
dc.subjectNecrosis-Factor-Alphaen
dc.subjectCytotoxic T-Cellsen
dc.subjectOf-The-Literatureen
dc.titleStevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Diseaseen
dc.typeinfo:eu-repo/semantics/article
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