One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure
| dc.contributor.author | Frussa-Filho, R. | |
| dc.contributor.author | Ribeiro, R. D. | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T12:33:25Z | |
| dc.date.available | 2016-01-24T12:33:25Z | |
| dc.date.issued | 2002-06-21 | |
| dc.description.abstract | A single exposure to the elevated plus-maze (EPM) test of anxiety reduces or abolishes the anxiolytic-like efficacy of benzodiazepines. This phenomenon called one-trial tolerance has been suggested to represent the acquisition of a phobic-like response to the open arms during trial 1. the present study was designed to examine the effects of chlordiazepoxide (5 mg/kg, ip) on the behaviour of rats in a conventional EPM apparatus after previous exposure to a four-open-arm EPM, a four-enclosed arm EPM or a conventional EPM, as well as in naive rats. Chlordiazepoxide had clear-cut anxiolytic-like effects (increased percentage of time spent on the open arms) in a traditional EPM in naive rats and in animals previously exposed to a four-open-arm EPM. However, it was ineffective in rats previously exposed to a traditional or a four-closed-arm EPM. Thus, the phenomenon of one-trial tolerance does not depend upon initial open-arm experience. (C) 2002 Elsevier Science Inc. All rights reserved. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, BR-04023062 São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Farmacol, Escola Paulista Med, BR-04023062 São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 519-525 | |
| dc.identifier | http://dx.doi.org/10.1016/S0024-3205(02)01709-5 | |
| dc.identifier.citation | Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 71, n. 5, p. 519-525, 2002. | |
| dc.identifier.doi | 10.1016/S0024-3205(02)01709-5 | |
| dc.identifier.issn | 0024-3205 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/26898 | |
| dc.identifier.wos | WOS:000176678700004 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | Life Sciences | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.subject | chlordiazepoxide | en |
| dc.subject | elevated plus-maze | en |
| dc.subject | tolerance | en |
| dc.subject | anxiety | en |
| dc.subject | phobia | en |
| dc.title | One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure | en |
| dc.type | info:eu-repo/semantics/article |