Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults

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dc.contributor.authorPrates Eleuterio, Sabrina Jeane [UNIFESP]
dc.contributor.authorSenerchia, Andreza Almeida [UNIFESP]
dc.contributor.authorAlmeida, Maria Teresa
dc.contributor.authorDa Costa, Cecilia Maria
dc.contributor.authorLustosa, Daniel
dc.contributor.authorCalheiros, Luiz Mario
dc.contributor.authorSilva Barreto, Jose Henrique
dc.contributor.authorBrunetto, Algemir Lunardi
dc.contributor.authorPacheco Donato Macedo, Carla Renata [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Canc AC Camargo
dc.contributor.institutionHosp Canc Ceara
dc.contributor.institutionSoc Pernambucana Combate Ao Canc
dc.contributor.institutionSoc Oncol Bahia
dc.contributor.institutionHosp Clin Porto Alegre
dc.date.accessioned2016-01-24T14:40:35Z
dc.date.available2016-01-24T14:40:35Z
dc.date.issued2015-07-01
dc.description.abstractBackgroundChildhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal.MethodsIn order to identify the main differences in clinicalpathologic features, surgical approaches and survival rates of primary high grade OST of the extremity between children (n=156; <12 years old) and AYA (n=397; 12-30 years old), the institutional database with 553 patients treated by BOTG studies over 15 years were reviewed.ResultsThere were no differences in metastasess at diagnosis, tumor size, and grade of necrosis between the two age groups. the rate of amputation was 30% higher in the children group (P=0.018). the rate of limb salvage surgery using reconstruction with allograft or autograft was 70% higher in the children group (P=0.018) while endoprosthesis rate was 40% higher in the AYA group (P=0.018). the log rank test revealed that survival is similar between the two age groups for non-metastatic patients (P=0.424 for OS and P=0.393 for EFS). Metastatic patients of both ages group had higher risk of dying compared to non-metastatic (HR 3.283 95% CI 2.581-4.177; P<0.001). Children with metastases at diagnosis had less OS time (P=0.049) and EFS time (P=0.032) than adolescents.ConclusionNon-metastatic OST in preadolescent patients does not appear to be significantly differentfrom those seen in AYA patients, but has local control challenges. Children presenting with metastases should be considered an ultra-high-risk group. Pediatr Blood Cancer 2015;62:1209-1213. (c) 2015 Wiley Periodicals, Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst Oncol Pediat GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Crianca, São Paulo, Brazil
dc.description.affiliationHosp Canc AC Camargo, São Paulo, Brazil
dc.description.affiliationHosp Canc Ceara, Fortaleza, Ceara, Brazil
dc.description.affiliationSoc Pernambucana Combate Ao Canc, Recife, PE, Brazil
dc.description.affiliationSoc Oncol Bahia, Salvador, BA, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Oncol Pediat GRAACC, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1209-1213
dc.identifierhttp://dx.doi.org/10.1002/pbc.25459
dc.identifier.citationPediatric Blood & Cancer. Hoboken: Wiley-Blackwell, v. 62, n. 7, p. 1209-1213, 2015.
dc.identifier.doi10.1002/pbc.25459
dc.identifier.issn1545-5009
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39145
dc.identifier.wosWOS:000354541600020
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPediatric Blood & Cancer
dc.rightsAcesso aberto
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectadolescenten
dc.subjectamputationen
dc.subjectchemotherapyen
dc.subjectchildhood bone canceren
dc.subjectChildrenen
dc.subjectosteosarcomaen
dc.subjectyoung adulten
dc.titleOsteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adultsen
dc.typeArtigo
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