Histological evolution of hepatitis C virus infection after renal transplantation

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dc.contributor.authorOliveira Uehara, Silvia Naomi de [UNIFESP]
dc.contributor.authorEmori, Christini Takemi [UNIFESP]
dc.contributor.authorPereira, Patrícia da Silva Fucuta [UNIFESP]
dc.contributor.authorPerez, Renata M.
dc.contributor.authorMedina Pestana, Jose Osmar
dc.contributor.authorLanzoni, Valeria Pereira
dc.contributor.authorSouza e Silva, Ivonete Sandra [UNIFESP]
dc.contributor.authorBenedito Silva, Antonio Eduardo [UNIFESP]
dc.contributor.authorFerraz, Maria Lucia Cardoso Gomes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.date.accessioned2016-01-24T14:27:59Z
dc.date.available2016-01-24T14:27:59Z
dc.date.issued2012-11-01
dc.description.abstractBackground: information regarding histological progression of hepatitis C after renal transplant (RTx) is scarce. Aims: To analyze clinical and laboratory evolution and histological progression of hepatitis C in patients evaluated before and after RTx.Methods: Twenty-two HCV-infected patients submitted to liver biopsy pre- and post-RTx were included. A semiquantitative analysis of necroinflammatory activity and fibrosis staging was performed and the two biopsies were compared.Results: Patients were mostly men (73%) with mean age of 36 +/- 9 yr. Time post-transplant was 4 +/- 2 yr and time between biopsies was 5 +/- 2 yr. An elevation of alanine aminotransferase (p = 0.041) and aspartate aminotransferase (p = 0.004) levels was observed in the post-transplant period. Fibrosis progression after renal transplantation was observed in 11 (50%) of the patients, and necroinflammatory activity worsening was observed in 7 (32%) of the patients. the histological progression occurred even among those without significant histological lesions in pre-transplant biopsy.Conclusion: the findings of this study suggest that the practice of indicating treatment in the pre-transplant phase based mainly on histological disease should be revised, because a high proportion of patients present disease progression. Because interferon cannot be used safely after RTx, treatment should be indicated for all ESRD patients with hepatitis C.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Div Hepatol, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Div Nephrol, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Pathol, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent842-848
dc.identifierhttp://dx.doi.org/10.1111/j.1399-0012.2012.01635.x
dc.identifier.citationClinical Transplantation. Hoboken: Wiley-Blackwell, v. 26, n. 6, p. 842-848, 2012.
dc.identifier.doi10.1111/j.1399-0012.2012.01635.x
dc.identifier.issn0902-0063
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35484
dc.identifier.wosWOS:000312129100015
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Transplantation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectchronic kidney failureen
dc.subjecthemodialysisen
dc.subjecthepatitis Cen
dc.subjectkidney transplantationen
dc.subjectliver diseaseen
dc.titleHistological evolution of hepatitis C virus infection after renal transplantationen
dc.typeinfo:eu-repo/semantics/article
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